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dyrb-1 Dynein light chain roadblock [ Caenorhabditis elegans ]

Gene ID: 188872, updated on 9-Dec-2024

Summary

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Official Symbol
dyrb-1
Official Full Name
Dynein light chain roadblock
Primary source
WormBase:WBGene00012004
Locus tag
CELE_T24H10.6
See related
AllianceGenome:WB:WBGene00012004
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Located in several cellular components, including cell cortex; microtubule cytoskeleton; and perinuclear region of cytoplasm. Is expressed in ciliated neurons and intestine. Orthologous to human DYNLRB1 (dynein light chain roadblock-type 1) and DYNLRB2 (dynein light chain roadblock-type 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dyrb-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
2
Sequence:
Chromosome: II; NC_003280.10 (9106515..9107145, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Putative transcription elongation factor S-II Neighboring gene Uncharacterized protein Neighboring gene J domain-containing protein Neighboring gene ncRNA Neighboring gene Transmembrane protein 53

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Intracellular organelles mediate cytoplasmic pulling force for centrosome centration in the Caenorhabditis elegans early embryo. Kimura K, et al. Proc Natl Acad Sci U S A, 2011 Jan 4. PMID 21173218, Free PMC Article
  2. Heterotrimeric G protein signaling functions with dynein to promote spindle positioning in C. elegans. Couwenbergs C, et al. J Cell Biol, 2007 Oct 8. PMID 17908918, Free PMC Article
  3. Insights on UNC-104-dynein/dynactin interactions and their implications on axonal transport in Caenorhabditis elegans. Chen CW, et al. J Neurosci Res, 2019 Feb. PMID 30311677
  4. A role for dynein in the inhibition of germ cell proliferative fate. Dorsett M, et al. Mol Cell Biol, 2009 Nov. PMID 19752194, Free PMC Article
  5. Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants. O'Rourke SM, et al. PLoS Genet, 2007 Aug. PMID 17676955, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. dyrb-1, is a potential subunit involved in dynein anchoring for centrosome centration and is required for organelle movement toward the minus end of the microtubules.
    Title: Intracellular organelles mediate cytoplasmic pulling force for centrosome centration in the Caenorhabditis elegans early embryo.
  2. DYRB-1 physically associates with LIN-5 and GPR-1/2.
    Title: Heterotrimeric G protein signaling functions with dynein to promote spindle positioning in C. elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein intermediate chain binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic dynein complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of dynein complex IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle microtubule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Dynein light chain roadblock
NP_495943.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    9106515..9107145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063542.7 → NP_495943.1  Dynein light chain roadblock [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_495943.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22752
    Conserved Domains (1) summary
    pfam03259
    Location:4 → 93
    Robl_LC7; Roadblock/LC7 domain
Nucleotide Protein
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