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T28B8.3 DUF3437 domain-containing protein;Proteasome activator complex subunit 4 C-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 189032, updated on 2-Nov-2024

Summary

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Official Symbol
T28B8.3
Official Full Name
DUF3437 domain-containing protein;Proteasome activator complex subunit 4 C-terminal domain-containing protein
Primary source
WormBase:WBGene00012114
Locus tag
CELE_T28B8.3
See related
AllianceGenome:WB:WBGene00012114
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable lysine-acetylated histone binding activity; peptidase activator activity; and proteasome binding activity. Predicted to be involved in proteasomal ubiquitin-independent protein catabolic process. Predicted to be part of proteasome complex. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See T28B8.3 in Genome Data Viewer
Location:
chromosome: I
Exon count:
22
Sequence:
Chromosome: I; NC_003279.8 (8151862..8159798)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene INSulin related Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene Proteasome activator complex subunit 4 Neighboring gene ncRNA Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables lysine-acetylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysine-acetylated histone binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables proteasome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proteasome binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteasomal ubiquitin-independent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DUF3437 domain-containing protein;Proteasome activator complex subunit 4 C-terminal domain-containing protein
NP_001040693.2
  • Partially confirmed by transcript evidence
NP_001364595.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    8151862..8159798
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001377608.2 → NP_001364595.1  DUF3437 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91834
    Conserved Domains (3) summary
    sd00044
    Location:1707 → 1739
    HEAT; HEAT repeat [structural motif]
    pfam11919
    Location:1804 → 1888
    DUF3437; Domain of unknown function (DUF3437)
    pfam16507
    Location:325 → 860
    BLM10_mid; Proteasome-substrate-size regulator, mid region

  2. NM_001047228.2 → NP_001040693.2  Proteasome activator complex subunit 4 C-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040693.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q1ZXS9
    Conserved Domains (2) summary
    sd00044
    Location:257 → 289
    HEAT; HEAT repeat [structural motif]
    pfam11919
    Location:354 → 438
    DUF3437; Domain of unknown function (DUF3437)
Nucleotide Protein
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