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nhx-8 Sodium/hydrogen exchanger [ Caenorhabditis elegans ]

Gene ID: 189474, updated on 4-Jan-2025

Summary

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Official Symbol
nhx-8
Official Full Name
Sodium/hydrogen exchanger
Primary source
WormBase:WBGene00003735
Locus tag
CELE_Y18D10A.6
See related
AllianceGenome:WB:WBGene00003735
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport and regulation of intracellular pH. Predicted to be located in Golgi membrane. Is expressed in several structures, including alimentary muscle; hypodermis; nervous system; pharyngeal-intestinal valve; and rectal valve cell. Orthologous to human SLC9A8 (solute carrier family 9 member A8). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See nhx-8 in Genome Data Viewer
Location:
chromosome: I
Exon count:
8
Sequence:
Chromosome: I; NC_003279.8 (12825664..12834163)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Glycogen synthase kinase-3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SSD domain-containing protein Neighboring gene Eukaryotic translation initiation factor 4E-binding protein Mextli homolog Neighboring gene putative cytosolic iron-sulfur protein assembly protein CIAO1 homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A DNA nanodevice for mapping sodium at single-organelle resolution. Zou J, et al. Nat Biotechnol, 2024 Jul. PMID 37735265, Free PMC Article
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium:proton antiporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of pH IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Sodium/hydrogen exchanger
NP_001021728.1
  • Confirmed by transcript evidence
NP_001021729.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    12825664..12834163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026557.4 → NP_001021728.1  Sodium/hydrogen exchanger [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021728.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBN7
    Conserved Domains (1) summary
    COG0025
    Location:109 → 517
    NhaP; NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]

  2. NM_001026558.5 → NP_001021729.1  Sodium/hydrogen exchanger [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021729.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFN1
    Conserved Domains (1) summary
    COG0025
    Location:83 → 491
    NhaP; NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]
Nucleotide Protein
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