Y38H6C.8 C-type lectin domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: Y38H6C.8
Official Full Name: C-type lectin domain-containing protein
Primary source: WormBase:WBGene00012621
Locus tag: CELE_Y38H6C.8
See related: AllianceGenome:WB:WBGene00012621
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable carbohydrate binding activity and pattern recognition receptor activity. Predicted to be involved in immune response. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human REG1A (regenerating family member 1 alpha); REG1B (regenerating family member 1 beta); and REG3G (regenerating family member 3 gamma). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See Y38H6C.8 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 3

Sequence:: Chromosome: V; NC_003283.11 (20513961..20515732)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y38H6C.7 (e-PCR)
- UniSTS:316186

Y38H6C.8 (e-PCR)
- UniSTS:317755

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables pattern recognition receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: C-type lectin domain-containing protein

NP_507951.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

20513961..20515732

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_075550.3 → NP_507951.1 C-type lectin domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_507951.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9XX56

Conserved Domains (1) summary

smart00034
Location:18 → 142

CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)