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epg-6 Ectopic P granules protein 6 [ Caenorhabditis elegans ]

Gene ID: 189705, updated on 4-Jan-2025

Summary

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Official Symbol
epg-6
Official Full Name
Ectopic P granules protein 6
Primary source
WormBase:WBGene00012641
Locus tag
CELE_Y39A1A.1
See related
AllianceGenome:WB:WBGene00012641
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables phosphatidylinositol phosphate binding activity. Involved in autophagosome assembly. Located in cytoplasm. Is expressed in several structures, including nervous system. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation 5. Orthologous to several human genes including WDR45 (WD repeat domain 45). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See epg-6 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (10596610..10600188, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ShKT domain-containing protein Neighboring gene rRNA methyltransferase 1, mitochondrial Neighboring gene Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Neighboring gene Reverse transcriptase domain-containing protein Neighboring gene Rab5 GDP/GTP exchange factor Neighboring gene Secreted protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATG-18 and EPG-6 are Both Required for Autophagy but Differentially Contribute to Lifespan Control in Caenorhabditis elegans. Takacs Z, et al. Cells, 2019 Mar 12. PMID 30871075, Free PMC Article
  2. WIPI-Mediated Autophagy and Longevity. Grimmel M, et al. Cells, 2015 May 22. PMID 26010754, Free PMC Article
  3. The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes. Lu Q, et al. Dev Cell, 2011 Aug 16. PMID 21802374
  4. The two C. elegans ATG-16 homologs have partially redundant functions in the basal autophagy pathway. Zhang H, et al. Autophagy, 2013 Dec. PMID 24185444, Free PMC Article
  5. A conserved requirement for RME-8/DNAJC13 in neuronal autophagic lysosome reformation. Swords SB, et al. Autophagy, 2024 Apr. PMID 37942902, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-5-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagy of peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein lipidation involved in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in phagophore assembly site membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagophore assembly site membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ectopic P granules protein 6
NP_001255083.1
  • Confirmed by transcript evidence
NP_001379429.1
  • Confirmed by transcript evidence
NP_499335.2
  • Confirmed by transcript evidence
NP_871659.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10596610..10600188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066934.5 → NP_499335.2  Ectopic P granules protein 6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499335.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XX21
    Conserved Domains (2) summary
    COG2319
    Location:9 → 320
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:80 → 124
    7WD40; WD40 repeat [structural motif]

  2. NM_001392195.1 → NP_001379429.1  Ectopic P granules protein 6 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    COG2319
    Location:10 → 288
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:48 → 92
    7WD40; WD40 repeat [structural motif]

  3. NM_181930.8 → NP_871659.1  Ectopic P granules protein 6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_871659.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E3CTH5, Q5DTE8, Q86MP3, Q9XX21
    Conserved Domains (2) summary
    COG2319
    Location:9 → 320
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:80 → 124
    7WD40; WD40 repeat [structural motif]

  4. NM_001268154.3 → NP_001255083.1  Ectopic P granules protein 6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255083.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E3CTH5
    Conserved Domains (2) summary
    COG2319
    Location:1 → 213
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:66 → 109
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86MP3.1

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