lgc-42 Ligand-Gated ion Channel [Caenorhabditis elegans] - Gene

Summary

Official Symbol: lgc-42
Official Full Name: Ligand-Gated ion Channel
Primary source: WormBase:WBGene00021437
Locus tag: CELE_Y39A3B.2
See related: AllianceGenome:WB:WBGene00021437
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable extracellular ligand-gated monoatomic ion channel activity and transmembrane signaling receptor activity. Predicted to be involved in excitatory postsynaptic potential and monoatomic ion transmembrane transport. Predicted to be located in plasma membrane and postsynapse. Human ortholog(s) of this gene implicated in hyperekplexia 1; hyperekplexia 2; and syndromic X-linked intellectual disability Pilorge type. Orthologous to several human genes including GLRA1 (glycine receptor alpha 1); GLRA2 (glycine receptor alpha 2); and GLRA3 (glycine receptor alpha 3). [provided by Alliance of Genome Resources, Jan 2025]
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Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info

NP_001391137.1

NP_497489.3

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The following sections contain reference sequences that belong to a specific genome build. Explain