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sws-1 SWIM-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 189734, updated on 4-Jan-2025

Summary

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Official Symbol
sws-1
Official Full Name
SWIM-type domain-containing protein
Primary source
WormBase:WBGene00012698
Locus tag
CELE_Y39B6A.40
See related
AllianceGenome:WB:WBGene00012698
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in double-strand break repair via homologous recombination. Predicted to be part of Shu complex. Human ortholog(s) of this gene implicated in 46 XX gonadal dysgenesis and spermatogenic failure 71. Orthologous to human ZSWIM7 (zinc finger SWIM-type containing 7). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See sws-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (18979319..18981479, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Small ribosomal subunit protein mS35 mitochondrial conserved domain-containing protein Neighboring gene REPS (RalBP1-associated Eps domain-containing protein) homolog Neighboring gene Structural protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CRISPR Technology Reveals RAD(51)-ical Mechanisms of Repair in Roundworms: An Educational Primer for Use with "Promotion of Homologous Recombination by SWS-1 in Complex with RAD-51 Paralogs in Caenorhabditis elegans". Turcotte CA, et al. Genetics, 2016 Nov. PMID 28114101, Free PMC Article
  2. Promotion of Homologous Recombination by SWS-1 in Complex with RAD-51 Paralogs in Caenorhabditis elegans. McClendon TB, et al. Genetics, 2016 May. PMID 26936927, Free PMC Article
  3. Evolutionary and functional analysis of the invariant SWIM domain in the conserved Shu2/SWS1 protein family from Saccharomyces cerevisiae to Homo sapiens. Godin SK, et al. Genetics, 2015 Apr. PMID 25659377, Free PMC Article
  4. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Shu complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SWIM-type domain-containing protein
NP_001300234.1
  • Confirmed by transcript evidence
NP_001300235.1
  • Confirmed by transcript evidence
NP_001380187.1
  • Confirmed by transcript evidence
NP_741657.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    18979319..18981479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001313305.2 → NP_001300234.1  SWIM-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AY91

  2. NM_171567.4 → NP_741657.2  SWIM-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741657.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MYM5

  3. NM_001392693.1 → NP_001380187.1  SWIM-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AV98

  4. NM_001313306.1 → NP_001300235.1  SWIM-type domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AT01
Nucleotide Protein
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