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zeel-1 TIR domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 189770, updated on 4-Jan-2025

Summary

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Official Symbol
zeel-1
Official Full Name
TIR domain-containing protein
Primary source
WormBase:WBGene00021463
Locus tag
CELE_Y39G10AR.5
See related
AllianceGenome:WB:WBGene00021463
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be located in membrane. Predicted to be part of Cul2-RING ubiquitin ligase complex. Is expressed in embryonic cell. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See zeel-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
13
Sequence:
Chromosome: I; NC_003279.8 (2342216..2350536)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene glucuronosyltransferase Neighboring gene pseudo Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A toxin-antidote selfish element increases fitness of its host. Long L, et al. Elife, 2023 Oct 24. PMID 37874324, Free PMC Article
  2. Genetics of the schizophrenias: a model accounting for their persistence and myriad phenotypes. Boshes RA, et al. Harv Rev Psychiatry, 2012 May-Jun. PMID 22716503
  3. A Powerful New Quantitative Genetics Platform, Combining Caenorhabditis elegans High-Throughput Fitness Assays with a Large Collection of Recombinant Strains. Andersen EC, et al. G3 (Bethesda), 2015 Mar 13. PMID 25770127, Free PMC Article
  4. A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion in C. elegans. Seidel HS, et al. PLoS Biol, 2011 Jul. PMID 21814493, Free PMC Article
  5. Widespread genetic incompatibility in C. elegans maintained by balancing selection. Seidel HS, et al. Science, 2008 Feb 1. PMID 18187622, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the peel-1/zeel-1 element in C. elegans is composed of two, tightly linked genes: a sperm-delivered toxin, peel-1, and an embryo-expressed antidote, zeel-1
    Title: A novel sperm-delivered toxin causes late-stage embryo lethality and transmission ratio distortion in C. elegans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TIR domain-containing protein
NP_490966.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    2342216..2350536
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058565.4 → NP_490966.2  TIR domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490966.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95XQ4
    Conserved Domains (1) summary
    sd00033
    Location:346 → 370
    LRR_RI; leucine-rich repeat [structural motif]
Nucleotide Protein
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