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wac-1.1 WW domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 189782, updated on 2-Nov-2024

Summary

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Official Symbol
wac-1.1
Official Full Name
WW domain-containing protein
Primary source
WormBase:WBGene00012734
Locus tag
CELE_Y40B1A.3
See related
AllianceGenome:WB:WBGene00012734
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA polymerase II complex binding activity and chromatin binding activity. Predicted to be involved in positive regulation of TORC1 signaling and regulation of autophagy. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See wac-1.1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
13
Sequence:
Chromosome: I; NC_003279.8 (13347066..13359643)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Obg-like ATPase 1 Neighboring gene WW domain-containing protein Neighboring gene Specificity protein transcription factor 3 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The TORC1 phosphoproteome in C. elegans reveals roles in transcription and autophagy. Sewell AK, et al. iScience, 2022 May 20. PMID 35479415, Free PMC Article
  2. DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans. Suen KM, et al. Nat Commun, 2020 Aug 25. PMID 32843637, Free PMC Article
  3. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
  4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA polymerase II complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
WW domain-containing protein
NP_001252144.1
  • Partially confirmed by transcript evidence
NP_001364501.1
  • Confirmed by transcript evidence
NP_001364502.1
  • Partially confirmed by transcript evidence
NP_001364574.1
  • Partially confirmed by transcript evidence
NP_001364671.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    13347066..13359643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001377669.2 → NP_001364671.1  WW domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1NZ12
    Conserved Domains (1) summary
    cd00201
    Location:9 → 38
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

  2. NM_001377668.2 → NP_001364501.1  WW domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9MND1
    Conserved Domains (1) summary
    pfam00397
    Location:9 → 36
    WW; WW domain

  3. NM_001377670.2 → NP_001364502.1  WW domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9MRL7

  4. NM_001377671.1 → NP_001364574.1  WW domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XW27

  5. NM_001265215.2 → NP_001252144.1  WW domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001252144.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5WWM0
Nucleotide Protein
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