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ego-2 BRO1 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 190251, updated on 4-Jan-2025

Summary

Official Symbol
ego-2
Official Full Name
BRO1 domain-containing protein
Primary source
WormBase:WBGene00001215
Locus tag
CELE_Y53H1C.2
See related
AllianceGenome:WB:WBGene00001215
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in positive regulation of Notch signaling pathway and protein localization to basolateral plasma membrane. Located in cytoplasm and nucleus. Is expressed widely. Orthologous to human PTPN23 (protein tyrosine phosphatase non-receptor type 23). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See ego-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
15
Sequence:
Chromosome: I; NC_003279.8 (11400143..11416433, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Amino acid transporter Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein of unknown function WSN domain-containing protein Neighboring gene RING-type E3 ubiquitin transferase

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
BRO1 domain-containing protein
NP_001076622.2
  • Confirmed by transcript evidence
NP_001251634.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    11400143..11416433 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001083153.6NP_001076622.2  BRO1 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001076622.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBN5
    Conserved Domains (4) summary
    cd09234
    Location:386722
    V_HD-PTP_like; Protein-interacting V-domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains
    PRK07764
    Location:8401227
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    PRK12323
    Location:11581299
    PRK12323; DNA polymerase III subunit gamma/tau
    cl14649
    Location:2381
    BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains
  2. NM_001264705.3NP_001251634.1  BRO1 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001251634.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H8ESG1
    Conserved Domains (4) summary
    cd09234
    Location:386722
    V_HD-PTP_like; Protein-interacting V-domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains
    PRK07764
    Location:8401227
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    PRK12323
    Location:11581308
    PRK12323; DNA polymerase III subunit gamma/tau
    cl14649
    Location:2381
    BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains