Ppm1b protein phosphatase 1B, magnesium dependent, beta isoform [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppm1bprovided by MGI
Official Full Name: protein phosphatase 1B, magnesium dependent, beta isoformprovided by MGI
Primary source: MGI:MGI:101841
See related: Ensembl:ENSMUSG00000061130 AllianceGenome:MGI:101841
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PP2CB
Summary: Predicted to enable protein serine/threonine phosphatase activity. Involved in N-terminal protein myristoylation and protein dephosphorylation. Located in cytosol and membrane. Is expressed in several structures, including blastocyst; early embryo; gonad; liver; and lung. Orthologous to human PPM1B (protein phosphatase, Mg2+/Mn2+ dependent 1B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 20.4), cerebellum adult (RPKM 16.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E4; 17 55.13 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (85264169..85331420)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (84956741..85023992)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ppm1b negatively regulates necroptosis through dephosphorylating Rip3 in vitro and in vivo.
Title: Ppm1b negatively regulates necroptosis through dephosphorylating Rip3.
the phosphatase PPM1B as a novel selective modulator of PPARgamma activity.
Title: The serine/threonine phosphatase PPM1B (PP2Cβ) selectively modulates PPARγ activity.
Although a non-myristoylated mutation (G2A) of PPM1A and PPM1B prevented membrane association, this relocalization did not likely cause the decreased activity towards AMPKalpha.
Title: N-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cells.
These observations suggest that relatively high PP2Cbeta expression is specifically required during the early stages of pre-implantation development.
Title: Disruption of the mouse protein Ser/Thr phosphatase 2Cbeta gene leads to early pre-implantation lethality.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE112607 (e-PCR)
- UniSTS:246126

NoName (e-PCR)
- UniSTS:237719

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MAP kinase serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in N-terminal protein myristoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interferon-beta production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of non-canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-threonine dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein phosphatase 1B

Names: PP2C-beta

NP_001152968.1

EC 3.1.3.16

NP_001152969.1

EC 3.1.3.16

NP_001152970.1

EC 3.1.3.16

NP_001398498.1

EC 3.1.3.16

NP_001398499.1

EC 3.1.3.16

NP_001398500.1

EC 3.1.3.16

NP_001398501.1

EC 3.1.3.16

NP_001398502.1

EC 3.1.3.16

NP_001398503.1

EC 3.1.3.16

NP_001398505.1

EC 3.1.3.16

NP_001398506.1

EC 3.1.3.16

NP_001398507.1

EC 3.1.3.16

NP_001398508.1

EC 3.1.3.16

NP_001398509.1

EC 3.1.3.16

NP_001398510.1

EC 3.1.3.16

NP_035281.1

EC 3.1.3.16

XP_006523923.1

EC 3.1.3.16

XP_011244624.1

EC 3.1.3.16

XP_036016306.1

EC 3.1.3.16

XP_036016308.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159496.2 → NP_001152968.1 protein phosphatase 1B isoform 1

See identical proteins and their annotated locations for NP_001152968.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC142103

Consensus CDS

CCDS50199.1

UniProtKB/TrEMBL

Q5BKS2, Q99NF7

Related

ENSMUSP00000079107.7, ENSMUST00000080217.14

Conserved Domains (2) summary

cd00143
Location:23 → 295

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

pfam07830
Location:289 → 365

PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
NM_001159497.1 → NP_001152969.1 protein phosphatase 1B isoform 3

See identical proteins and their annotated locations for NP_001152969.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses alternate 5' and 3' UTRs and 3' coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

BB615769, BQ176513, D45860

Consensus CDS

CCDS50201.1

UniProtKB/Swiss-Prot

P36993

Related

ENSMUSP00000107924.4, ENSMUST00000112305.10

Conserved Domains (2) summary

cd00143
Location:23 → 295

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

pfam07830
Location:289 → 368

PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
NM_001159498.3 → NP_001152970.1 protein phosphatase 1B isoform 4

See identical proteins and their annotated locations for NP_001152970.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses alternate 5' and 3' UTRs and 3' coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC142103

Consensus CDS

CCDS50200.1

UniProtKB/Swiss-Prot

P36993

Related

ENSMUSP00000157282.2, ENSMUST00000234540.2

Conserved Domains (2) summary

cd00143
Location:23 → 295

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

pfam07830
Location:289 → 368

PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
NM_001411569.1 → NP_001398498.1 protein phosphatase 1B isoform 1

Status: VALIDATED

Source sequence(s)

AC142103

UniProtKB/TrEMBL

Q99NF7
NM_001411570.1 → NP_001398499.1 protein phosphatase 1B isoform 1

Status: VALIDATED

Source sequence(s)

AC142103

UniProtKB/TrEMBL

Q99NF7
NM_001411571.1 → NP_001398500.1 protein phosphatase 1B isoform 5

Status: VALIDATED

Source sequence(s)

AC142103
NM_001411572.1 → NP_001398501.1 protein phosphatase 1B isoform 3

Status: VALIDATED

Source sequence(s)

AC142103
NM_001411573.1 → NP_001398502.1 protein phosphatase 1B isoform 3

Status: VALIDATED

Source sequence(s)

AC142103

Related

ENSMUSP00000157013.2, ENSMUST00000234332.2
NM_001411574.1 → NP_001398503.1 protein phosphatase 1B isoform 3

Status: VALIDATED

Source sequence(s)

AC142103
NM_001411576.1 → NP_001398505.1 protein phosphatase 1B isoform 4

Status: VALIDATED

Source sequence(s)

AC142103

Related

ENSMUSP00000107926.4, ENSMUST00000112307.4
NM_001411577.1 → NP_001398506.1 protein phosphatase 1B isoform 4

Status: VALIDATED

Source sequence(s)

AC142103
NM_001411578.1 → NP_001398507.1 protein phosphatase 1B isoform 4

Status: VALIDATED

Source sequence(s)

AC142103
NM_001411579.1 → NP_001398508.1 protein phosphatase 1B isoform 6

Status: VALIDATED

Source sequence(s)

AC142103
NM_001411580.1 → NP_001398509.1 protein phosphatase 1B isoform 2

Status: VALIDATED

Source sequence(s)

AC142103

UniProtKB/Swiss-Prot

P36993

UniProtKB/TrEMBL

Q546R1
NM_001411581.1 → NP_001398510.1 protein phosphatase 1B isoform 7

Status: VALIDATED

Source sequence(s)

AC142103
NM_011151.3 → NP_035281.1 protein phosphatase 1B isoform 2

See identical proteins and their annotated locations for NP_035281.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents the longest transcript. Variant 2 uses an alternate 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC142103

Consensus CDS

CCDS37710.1

UniProtKB/Swiss-Prot

P36993

UniProtKB/TrEMBL

Q546R1, Q5BKS2

Related

ENSMUSP00000107923.3, ENSMUST00000112304.10

Conserved Domains (2) summary

cd00143
Location:23 → 295

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

pfam07830
Location:289 → 365

PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

RNA

NR_177287.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC142103

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

85264169..85331420

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160413.1 → XP_036016306.1 protein phosphatase 1B isoform X2

Conserved Domains (2) summary

cd00143
Location:23 → 295

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

pfam07830
Location:289 → 368

PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
XM_036160415.1 → XP_036016308.1 protein phosphatase 1B isoform X3

Conserved Domains (2) summary

cd00143
Location:23 → 295

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

pfam07830
Location:289 → 368

PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
XM_011246322.3 → XP_011244624.1 protein phosphatase 1B isoform X1

See identical proteins and their annotated locations for XP_011244624.1

UniProtKB/TrEMBL

Q5BKS2, Q99NF7

Conserved Domains (2) summary

cd00143
Location:23 → 295

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

pfam07830
Location:289 → 365

PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
XM_006523860.4 → XP_006523923.1 protein phosphatase 1B isoform X1

See identical proteins and their annotated locations for XP_006523923.1

UniProtKB/TrEMBL

Q5BKS2, Q99NF7

Conserved Domains (2) summary

cd00143
Location:23 → 295

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

pfam07830
Location:289 → 365

PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain