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aptf-2 Transcription factor aptf-2 [ Caenorhabditis elegans ]

Gene ID: 190458, updated on 9-Dec-2024

Summary

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Official Symbol
aptf-2
Official Full Name
Transcription factor aptf-2
Primary source
WormBase:WBGene00013383
Locus tag
CELE_Y62E10A.17
See related
AllianceGenome:WB:WBGene00013383
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and regulation of cell population proliferation. Located in cytoplasm and nucleus. Is expressed in AB lineage cell and C lineage cell. Human ortholog(s) of this gene implicated in branchiooculofacial syndrome. Orthologous to human TFAP2A (transcription factor AP-2 alpha). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See aptf-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (13413555..13416051, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene CYtochrome P450 family Neighboring gene Neuropeptide-Like Protein Neighboring gene BTB domain-containing protein Neighboring gene Pelle-like serine/threonine-protein kinase pik-1 Neighboring gene ncRNA Neighboring gene Polynucleotide 5'-hydroxyl-kinase nol-9

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The AP-2 Transcription Factor APTF-2 Is Required for Neuroblast and Epidermal Morphogenesis in Caenorhabditis elegans Embryogenesis. Budirahardja Y, et al. PLoS Genet, 2016 May. PMID 27176626, Free PMC Article
  2. A somatic proteoglycan controls Notch-directed germ cell fate. Gopal S, et al. Nat Commun, 2021 Nov 18. PMID 34795288, Free PMC Article
  3. Viable maternal-effect mutations that affect the development of the nematode Caenorhabditis elegans. Hekimi S, et al. Genetics, 1995 Dec. PMID 8601479, Free PMC Article
  4. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
  5. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Transcription factor aptf-2
NP_001255740.1
  • Confirmed by transcript evidence
NP_001255741.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    13413555..13416051 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268812.3 → NP_001255741.1  Transcription factor aptf-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255741.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U1W4
    Conserved Domains (1) summary
    pfam03299
    Location:147 → 341
    TF_AP-2; Transcription factor AP-2

  2. NM_001268811.3 → NP_001255740.1  Transcription factor aptf-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255740.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G2HK15, Q9U1W4
    Conserved Domains (1) summary
    pfam03299
    Location:151 → 346
    TF_AP-2; Transcription factor AP-2
Nucleotide Protein
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