Ppy pancreatic polypeptide [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppyprovided by MGI
Official Full Name: pancreatic polypeptideprovided by MGI
Primary source: MGI:MGI:97753
See related: Ensembl:ENSMUSG00000017316 AllianceGenome:MGI:97753
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PP; IGSPP
Summary: Enables G protein-coupled receptor binding activity. Predicted to be involved in feeding behavior and neuropeptide signaling pathway. Located in cytoplasm and extracellular space. Is expressed in several structures, including gut. Orthologous to human PPY (pancreatic polypeptide). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in colon adult (RPKM 58.6) and genital fat pad adult (RPKM 18.9) See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 65.48 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (101990757..101992145, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (102099931..102101319, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pancreatic Ppy-expressing gamma-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production.
Title: Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production.
GPR120 Regulates Pancreatic Polypeptide Secretion From Male Mouse Islets via PLC-Mediated Calcium Mobilization.
Title: GPR120 Regulates Pancreatic Polypeptide Secretion From Male Mouse Islets via PLC-Mediated Calcium Mobilization.
These data demonstrate glucose-regulated secretion of PP and its effects on glucagon release through PPYR1 receptors expressed by alpha-cells.
Title: Pancreatic polypeptide regulates glucagon release through PPYR1 receptors expressed in mouse and human alpha-cells.
PP-initiated signaling through Npy6r in vasoactive intestinal peptide neurons regulates the growth hormone axis and body composition.
Title: Pancreatic polypeptide controls energy homeostasis via Npy6r signaling in the suprachiasmatic nucleus in mice.
investigated the role of metalloendopeptidases in PYY(3-36) degradation and determined whether modulation of these enzymes enhanced PYY(3-36) plasma levels and bioactivity in vivo.
Title: A role for metalloendopeptidases in the breakdown of the gut hormone, PYY 3-36.
Pancreatic polypeptide enhances colonic contractile activity and fecal output through neuropeptide Y Y(4) receptor, and a neuropeptide Y Y(4) receptor agonist might offer a novel therapeutic approach to ameliorate constipation.
Title: Pancreatic polypeptide enhances colonic muscle contraction and fecal output through neuropeptide Y Y4 receptor in mice.
67.74% A-cells (glucagon-secreting cells) had PP (pancreatic polypeptide) immunoreactivity, 70.92% PP-cells contained glucagon immunoreactivity with immunofluorescence double staining
Title: Immunohistochemical localization of glucagon and pancreatic polypeptide on rat endocrine pancreas: coexistence in rat islet cells.
In adult mice, the misexpression of Arx, rather than its overexpression, promotes a conversion of beta cells into glucagon- or PP-producing cells in vivo.
Title: Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression.
Pancreatic polypeptide may influence food intake, energy metabolism, and the expression of hypothalamic peptides and gastric ghrelin.
Title: Characterization of the effects of pancreatic polypeptide in the regulation of energy balance.
impaired glucose tolerance in overexprsesing mice
Title: Impaired glucose tolerance in pancreatic polypeptide-overexpressing mice.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Gene trapped (1)
Targeted (3) 1 citation

General gene information

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Markers

Ppy (e-PCR), detects polymorphism
- UniSTS:507950

D10Wox17 (e-PCR)
- UniSTS:118117

D11Kyo1 (e-PCR), detects polymorphism
- UniSTS:118117

M18208 (e-PCR)
- UniSTS:180330

AV061413 (e-PCR)
- UniSTS:180333

NoName (e-PCR)
- UniSTS:489096

PMC24644P2 (e-PCR)
- UniSTS:272268

PMC24644P3 (e-PCR)
- UniSTS:272269

Ppy (e-PCR), detects polymorphism
- UniSTS:516531

Ppy (e-PCR), detects polymorphism
- UniSTS:256692

Ppy (e-PCR), detects polymorphism
- UniSTS:547525

M18208 (e-PCR)
- UniSTS:124924

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide Y receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in feeding behavior	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: pancreatic polypeptide prohormone

Names: pancreatic prohormone

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.