nhr-41 Nuclear Hormone Receptor family;Nuclear hormone receptor E75;Nuclear receptor [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nhr-41
Official Full Name: Nuclear Hormone Receptor family;Nuclear hormone receptor E75;Nuclear receptor
Primary source: WormBase:WBGene00022423
Locus tag: CELE_Y104H12A.1
See related: AllianceGenome:WB:WBGene00022423
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including excretory cell; hypodermis; intestine; neurons; and vulva. Orthologous to human NR2C1 (nuclear receptor subfamily 2 group C member 1) and NR2C2 (nuclear receptor subfamily 2 group C member 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See nhr-41 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 11

Sequence:: Chromosome: IV; NC_003282.8 (1386215..1399353)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y77E11A_3443.a (e-PCR)
- UniSTS:324207

Y104H12A.1 (e-PCR)
- UniSTS:320425

STS4-105 (e-PCR)
- UniSTS:242092

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nuclear Hormone Receptor family;Nuclear hormone receptor E75;Nuclear receptor

NP_001294480.1

Confirmed by transcript evidence

NP_001294481.1

Confirmed by transcript evidence

NP_001294505.1

Partially confirmed by transcript evidence

NP_001294506.1

Confirmed by transcript evidence

NP_500073.3

Product from WormBase gene class nhr;
Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

1386215..1399353

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067672.6 → NP_500073.3 Nuclear Hormone Receptor family [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q6V7L1, Q6V7L2, Q6V7L3, Q9N4B8

UniProtKB/TrEMBL

G4RWX6, Q3V5L2

Conserved Domains (3) summary

cd06967
Location:147 → 233

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

smart00818
Location:6 → 105

Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth

cl11397
Location:339 → 582

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001307551.3 → NP_001294480.1 Nuclear hormone receptor E75 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294480.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PRQ4

Conserved Domains (2) summary

cl02596
Location:79 → 165

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

cl11397
Location:271 → 514

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001307552.3 → NP_001294481.1 Nuclear hormone receptor E75 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294481.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PEU7

Conserved Domains (2) summary

cl02596
Location:45 → 131

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

cl11397
Location:237 → 480

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001307576.3 → NP_001294505.1 Nuclear hormone receptor E75 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294505.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PMI0

Conserved Domains (2) summary

cl02596
Location:63 → 149

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

cl11397
Location:255 → 498

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
NM_001307577.3 → NP_001294506.1 Nuclear receptor [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294506.1

Status: REVIEWED

UniProtKB/TrEMBL

U4PRT9

Conserved Domains (2) summary

cl02596
Location:23 → 109

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

cl11397
Location:215 → 458

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators