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sql-1 GRIP domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 190949, updated on 9-Dec-2024

Summary

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Official Symbol
sql-1
Official Full Name
GRIP domain-containing protein
Primary source
WormBase:WBGene00013730
Locus tag
CELE_Y111B2A.4
See related
AllianceGenome:WB:WBGene00013730
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable small GTPase binding activity. Predicted to be involved in Golgi organization and endoplasmic reticulum to Golgi vesicle-mediated transport. Located in Golgi apparatus. Human ortholog(s) of this gene implicated in achondrogenesis type IA. Orthologous to human TRIP11 (thyroid hormone receptor interactor 11). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sql-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
19
Sequence:
Chromosome: III; NC_003281.10 (12499557..12528052)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Mitochondrial cytochrome c oxidase subunit VIc/VIIs domain-containing protein Neighboring gene Helicase sen1 Neighboring gene pseudo Neighboring gene pseudo Neighboring gene CBS domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SQL-1, homologue of the Golgi protein GMAP210, modulates intraflagellar transport in C. elegans. Broekhuis JR, et al. J Cell Sci, 2013 Apr 15. PMID 23444385
  2. Genetic impairment of autophagy intensifies expanded polyglutamine toxicity in Caenorhabditis elegans. Khan LA, et al. Biochem Biophys Res Commun, 2008 Apr 11. PMID 18261464
  3. DLK-1/p38 MAP Kinase Signaling Controls Cilium Length by Regulating RAB-5 Mediated Endocytosis in Caenorhabditis elegans. van der Vaart A, et al. PLoS Genet, 2015 Dec. PMID 26657059, Free PMC Article
  4. The golgin coiled-coil proteins of the Golgi apparatus. Munro S. Cold Spring Harb Perspect Biol, 2011 Jun 1. PMID 21436057, Free PMC Article
  5. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
GRIP domain-containing protein
NP_001255174.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    12499557..12528052
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268245.3 → NP_001255174.1  GRIP domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255174.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0Z5P0
    Conserved Domains (1) summary
    COG1196
    Location:394 → 1184
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RNA

  1. NR_052807.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
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