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Prl6a1 prolactin family 6, subfamily a, member 1 [ Mus musculus (house mouse) ]

Gene ID: 19111, updated on 27-Nov-2024

Summary

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Official Symbol
Prl6a1provided by MGI
Official Full Name
prolactin family 6, subfamily a, member 1provided by MGI
Primary source
MGI:MGI:1206579
See related
Ensembl:ENSMUSG00000069259 AllianceGenome:MGI:1206579
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ghd10; PLP-B; Prlpb
Summary
Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in extraembryonic component and placenta. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward placenta adult (RPKM 66.5) See more
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Genomic context

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See Prl6a1 in Genome Data Viewer
Location:
13 A3.1; 13 12.39 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (27496598..27503237)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (27312615..27319254)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene prolactin family 3, subfamily b, member 1 Neighboring gene prolactin family 3, subfamily a, member 1 Neighboring gene craniofacial development protein 1 pseudogene Neighboring gene prolactin family 8, subfamily a, member 2 Neighboring gene STARR-seq mESC enhancer starr_34015 Neighboring gene prolactin family 2, subfamily b, member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Homologues for prolactin-like proteins A and B are present in the mouse. Müller H, et al. Biol Reprod, 1998 Jan. PMID 9472921
  2. Expression of mouse 17beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase type 7 in the ovary, uterus, and placenta: localization from implantation to late pregnancy. Nokelainen P, et al. Endocrinology, 2000 Feb. PMID 10650959
  3. Three new members of the mouse prolactin/growth hormone family are homologous to proteins expressed in the rat. Lin J, et al. Endocrinology, 1997 Dec. PMID 9389542
  4. Two novel members of the prolactin/growth hormone family are expressed in the mouse placenta. Lin J, et al. Endocrinology, 1997 Dec. PMID 9389541
  5. miR-126 regulates glycogen trophoblast proliferation and DNA methylation in the murine placenta. Sharma A, et al. Dev Biol, 2019 May 1. PMID 30771304, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hormone activity IEA
Inferred from Electronic Annotation
more info
  
enables prolactin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in female pregnancy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mammary gland development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of lactation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to nutrient levels IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
prolactin-6A1
Names
PRL-like protein B
growth hormone d10
placental prolactin-like protein B
prolactin-like protein B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001382844.1 → NP_001369773.1  prolactin-6A1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL592443
    UniProtKB/TrEMBL
    Q5SXJ8
    Conserved Domains (1) summary
    cd10288
    Location:29 → 229
    prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

  2. NM_011166.2 → NP_035296.1  prolactin-6A1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_035296.1

    Status: VALIDATED

    Source sequence(s)
    AF015563
    Consensus CDS
    CCDS26395.1
    UniProtKB/Swiss-Prot
    O35257
    UniProtKB/TrEMBL
    A0A0M6L0L9, Q5SXJ8
    Related
    ENSMUSP00000089269.3, ENSMUST00000091680.9
    Conserved Domains (1) summary
    cd10288
    Location:30 → 230
    prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    27496598..27503237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35257.1 GenPept UniProtKB/Swiss-Prot:O35257

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