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kgb-2 Stress-activated protein kinase JNK [ Caenorhabditis elegans ]

Gene ID: 191169, updated on 4-Jan-2025

Summary

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Official Symbol
kgb-2
Official Full Name
Stress-activated protein kinase JNK
Primary source
WormBase:WBGene00002188
Locus tag
CELE_ZC416.4
See related
AllianceGenome:WB:WBGene00002188
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable JUN kinase activity. Predicted to be involved in JNK cascade. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See kgb-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
9
Sequence:
Chromosome: IV; NC_003282.8 (3606784..3609229)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene BRCT domain-containing protein Neighboring gene Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal domain-containing protein Neighboring gene Choline O-acetyltransferase Neighboring gene Vesicular acetylcholine transporter unc-17 Neighboring gene Cysteine-rich transmembrane CYSTM domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Triphenyl phosphate induced reproductive toxicity through the JNK signaling pathway in Caenorhabditis elegans. Shi C, et al. J Hazard Mater, 2023 Mar 15. PMID 36586333
  2. Intrinsic JNK-MAPK pathway involvement requires daf-16-mediated immune response during Shigella flexneri infection in C. elegans. Marudhupandiyan S, et al. Immunol Res, 2017 Jun. PMID 27838822
  3. Evolutionary conserved role of c-Jun-N-terminal kinase in CO2-induced epithelial dysfunction. Vadász I, et al. PLoS One, 2012. PMID 23056407, Free PMC Article
  4. MAPping innate immunity. Young JA, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15328410, Free PMC Article
  5. The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response. Mizuno T, et al. EMBO J, 2004 Jun 2. PMID 15116070, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. responsible for the immune response elicited by the host during the Shigella flexneri infection
    Title: Intrinsic JNK-MAPK pathway involvement requires daf-16-mediated immune response during Shigella flexneri infection in C. elegans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables JUN kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Stress-activated protein kinase JNK
NP_500384.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    3606784..3609229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067983.4 → NP_500384.2  Stress-activated protein kinase JNK [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500384.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZI0
    Conserved Domains (2) summary
    smart00220
    Location:29 → 326
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:28 → 329
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
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