gbb-2 Gamma-aminobutyric acid type B receptor subunit 2 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: gbb-2
Official Full Name: Gamma-aminobutyric acid type B receptor subunit 2
Primary source: WormBase:WBGene00022675
Locus tag: CELE_ZK180.1
See related: AllianceGenome:WB:WBGene00022675
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables G protein-coupled GABA receptor activity. Involved in G protein-coupled receptor signaling pathway; negative regulation of cholinergic synaptic transmission; and response to xenobiotic stimulus. Predicted to be located in plasma membrane. Predicted to be part of G protein-coupled receptor heterodimeric complex. Human ortholog(s) of this gene implicated in alcohol use disorder; developmental and epileptic encephalopathy 59; and nicotine dependence. Orthologous to human GABBR2 (gamma-aminobutyric acid type B receptor subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

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Function	Evidence Code	Pubs
enables G protein-coupled GABA receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled GABA receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled GABA receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gamma-aminobutyric acid signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of synaptic transmission, cholinergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of G protein-coupled GABA receptor complex	TAS Traceable Author Statement more info	PubMed
part_of G protein-coupled receptor heterodimeric complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

NP_500579.3

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The following sections contain reference sequences that belong to a specific genome build. Explain