mett-10 U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mett-10
Official Full Name: U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase
Primary source: WormBase:WBGene00014228
Locus tag: CELE_ZK1128.2
See related: AllianceGenome:WB:WBGene00014228
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables U6 snRNA (adenine-(43)-N(6))-methyltransferase activity and mRNA m(6)A methyltransferase activity. Involved in several processes, including centrosome cycle; regulation of gene expression; and vulval development. Located in nucleus. Is expressed in germ line; gonad; intestine; and vulva. Orthologous to human METTL16 (methyltransferase 16, RNA N6-adenosine). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See mett-10 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (10115036..10116866)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structure of the Caenorhabditis elegans m6A methyltransferase METT10 that regulates SAM homeostasis.
Title: Structure of the Caenorhabditis elegans m6A methyltransferase METT10 that regulates SAM homeostasis.
METT-10 functions to inhibit germ-cell proliferative fate, despite promoting mitotic cell cycle progression of those germ cells that do proliferate, separates the specification of proliferative fate from its execution.
Title: METT-10, a putative methyltransferase, inhibits germ cell proliferative fate in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK1128.1 (e-PCR)
- UniSTS:308252

ZK1128.2 (e-PCR)
- UniSTS:308253

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables U6 snRNA (adenine-(43)-N(6))-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables mRNA m(6)A methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in centrosome cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA modification	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in metabolic process	IEA Inferred from Electronic Annotation more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
involved_in post-transcriptional regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in rRNA base methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in vulval development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase

NP_001379069.1

Confirmed by transcript evidence

NP_871660.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

10115036..10116866

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392185.1 → NP_001379069.1 U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09357, Q8I4B2

Conserved Domains (1) summary

cl17173
Location:1 → 303

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_181931.10 → NP_871660.1 U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_871660.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09357

Conserved Domains (1) summary

cl17173
Location:40 → 288

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...