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Cyth1 cytohesin 1 [ Mus musculus (house mouse) ]

Gene ID: 19157, updated on 27-Nov-2024

Summary

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Official Symbol
Cyth1provided by MGI
Official Full Name
cytohesin 1provided by MGI
Primary source
MGI:MGI:1334257
See related
Ensembl:ENSMUSG00000017132 AllianceGenome:MGI:1334257
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CLM1; CTH-1; CYTIP; Pscd1
Summary
Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within establishment of epithelial cell polarity. Located in bicellular tight junction; cytoplasmic side of plasma membrane; and cytosol. Is expressed in nervous system. Orthologous to human CYTH1 (cytohesin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in cerebellum adult (RPKM 19.7), frontal lobe adult (RPKM 16.5) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Cyth1 in Genome Data Viewer
Location:
11 E2; 11 82.96 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (118054996..118139452, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (118164170..118248616, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, heavy chain 17 Neighboring gene STARR-positive B cell enhancer ABC_E9849 Neighboring gene predicted gene 11738 Neighboring gene STARR-seq mESC enhancer starr_31297 Neighboring gene predicted gene, 38514 Neighboring gene STARR-positive B cell enhancer mm9_chr11:118017777-118018078 Neighboring gene STARR-positive B cell enhancer ABC_E7106 Neighboring gene STARR-positive B cell enhancer ABC_E9850 Neighboring gene VISTA enhancer mm1622 Neighboring gene STARR-positive B cell enhancer ABC_E5309 Neighboring gene STARR-positive B cell enhancer mm9_chr11:118109942-118110243 Neighboring gene STARR-positive B cell enhancer ABC_E9851 Neighboring gene STARR-positive B cell enhancer ABC_E1852 Neighboring gene ubiquitin specific peptidase 36 Neighboring gene STARR-seq mESC enhancer starr_31299 Neighboring gene tissue inhibitor of metalloproteinase 2 Neighboring gene CEP295 N-terminal like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and sequencing of cDNA encoding mouse cytohesin-1. O'Rourke AM, et al. Immunogenetics, 1998 Oct. PMID 9745014
  2. Cloning and characterization of the promoter of murine cytohesin-1 gene. Goda N, et al. Biochim Biophys Acta, 2000 Sep 7. PMID 10978522
  3. A natural loss-of-function deletion of the cytohesin 1 (Cyth1) gene in BALB/cByJ mice does not impact cardiomyocyte polyploidy. Song R, et al. Sci Rep, 2024 Jun 10. PMID 38858421, Free PMC Article
  4. Anti-proliferative effect of cytohesin inhibition in gefitinib-resistant lung cancer cells. Bill A, et al. PLoS One, 2012. PMID 22815959, Free PMC Article
  5. Signaling through Arf6 guanine-nucleotide exchange factor cytohesin-1 regulates migration in Schwann cells. Miyamoto Y, et al. Cell Signal, 2013 Jun. PMID 23517829

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A natural loss-of-function deletion of the cytohesin 1 (Cyth1) gene in BALB/cByJ mice does not impact cardiomyocyte polyploidy.
    Title: A natural loss-of-function deletion of the cytohesin 1 (Cyth1) gene in BALB/cByJ mice does not impact cardiomyocyte polyploidy.
  2. Cytohesin-1 is required for Schwann cell migration and that phosphorylation of cytohesin-1 at the Tyr-382 position is important for migration.
    Title: Signaling through Arf6 guanine-nucleotide exchange factor cytohesin-1 regulates migration in Schwann cells.
  3. Phosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development.
    Title: Phosphorylation of cytohesin-1 by Fyn is required for initiation of myelination and the extent of myelination during development.
  4. cytohesin inhibition has an antiproliferative effect in gefitinib-resistant lung cancer cells
    Title: Anti-proliferative effect of cytohesin inhibition in gefitinib-resistant lung cancer cells.
  5. demonstrate an essential role of cytohesin-1/RhoA during ameboid migration in the presence of integrins
    Title: Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • KIAA4240

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within establishment of epithelial cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in presynaptic modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
  
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extrinsic component of presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
cytohesin-1
Names
PH, SEC7 and coiled-coil domain-containing protein 1
SEC7 homolog A
mSec7-1
pleckstrin homology, Sec7 and coiled-coil domains 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112699.2 → NP_001106169.1  cytohesin-1 isoform 2

    See identical proteins and their annotated locations for NP_001106169.1

    Status: VALIDATED

    Source sequence(s)
    AL591109, AL591204, AL591404
    Consensus CDS
    CCDS48997.1
    UniProtKB/TrEMBL
    Q3T9T9, Q8K3E8
    Related
    ENSMUSP00000017276.8, ENSMUST00000017276.14
    Conserved Domains (2) summary
    cd01252
    Location:259 → 378
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:62 → 244
    Sec7; Sec7 domain

  2. NM_001112700.2 → NP_001106170.1  cytohesin-1 isoform 3

    See identical proteins and their annotated locations for NP_001106170.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AL591109, AL591204
    UniProtKB/TrEMBL
    Q3T9T9, Q3TZ02
    Conserved Domains (4) summary
    cd01252
    Location:261 → 381
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam00169
    Location:265 → 379
    PH; PH domain
    pfam01369
    Location:64 → 246
    Sec7; Sec7 domain
    cl19219
    Location:8 → 90
    DUF342; Protein of unknown function (DUF342)

  3. NM_001378885.1 → NP_001365814.1  cytohesin-1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL591109, AL591204
    UniProtKB/TrEMBL
    B1AQE4, Q3T9T9
    Related
    ENSMUSP00000114792.3, ENSMUST00000151165.3
    Conserved Domains (2) summary
    cd01252
    Location:261 → 380
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:64 → 246
    Sec7; Sec7 domain

  4. NM_001378886.1 → NP_001365815.1  cytohesin-1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL591109, AL591204
    UniProtKB/TrEMBL
    Q3T9T9
    Conserved Domains (2) summary
    cd01252
    Location:200 → 319
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:3 → 185
    Sec7; Sec7 domain

  5. NM_001378887.1 → NP_001365816.1  cytohesin-1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL591109, AL591404
    Conserved Domains (1) summary
    pfam01369
    Location:62 → 244
    Sec7; Sec7 domain

  6. NM_001378888.1 → NP_001365817.1  cytohesin-1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL591109
    Conserved Domains (1) summary
    pfam01369
    Location:3 → 185
    Sec7; Sec7 domain

  7. NM_011180.4 → NP_035310.2  cytohesin-1 isoform 1

    See identical proteins and their annotated locations for NP_035310.2

    Status: VALIDATED

    Source sequence(s)
    AL591109, AL591204, AL591404
    UniProtKB/Swiss-Prot
    O88817, Q76MU4, Q9QX11
    UniProtKB/TrEMBL
    Q3T9T9
    Conserved Domains (2) summary
    cd01252
    Location:259 → 379
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:62 → 244
    Sec7; Sec7 domain

RNA

  1. NR_166155.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591109, AL591204

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    118054996..118139452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532519.5 → XP_006532582.1  cytohesin-1 isoform X1

    See identical proteins and their annotated locations for XP_006532582.1

    UniProtKB/TrEMBL
    Q3T9T9
    Conserved Domains (2) summary
    cd01252
    Location:200 → 320
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:3 → 185
    Sec7; Sec7 domain

  2. XM_011248805.4 → XP_011247107.1  cytohesin-1 isoform X2

    Conserved Domains (1) summary
    pfam01369
    Location:64 → 246
    Sec7; Sec7 domain

RNA

  1. XR_003949350.2 RNA Sequence

  2. XR_001779921.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QX11.2 GenPept UniProtKB/Swiss-Prot:Q9QX11

Gene LinkOut

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