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Fat3 FAT atypical cadherin 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 191571, updated on 27-Nov-2024

Summary

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Official Symbol
Fat3provided by RGD
Official Full Name
FAT atypical cadherin 3provided by RGD
Primary source
RGD:620657
See related
EnsemblRapid:ENSRNOG00000011585 AllianceGenome:RGD:620657
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in cell-cell adhesion. Predicted to act upstream of or within generation of neurons; negative regulation of dendrite development; and retina layer formation. Predicted to be located in dendrite. Orthologous to human FAT3 (FAT atypical cadherin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 107.4), Kidney (RPKM 29.0) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fat3 in Genome Data Viewer
Location:
8q12
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (20972840..21555679, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (12691470..13274336, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (14417039..15011596, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479966 Neighboring gene melatonin receptor 1B Neighboring gene uncharacterized LOC102553833 Neighboring gene mortality factor 4 like 1, pseudogene 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mammalian fat3: a large protein that contains multiple cadherin and EGF-like motifs. Mitsui K, et al. Biochem Biophys Res Commun, 2002 Feb 1. PMID 11811999
  2. Control of neuronal morphology by the atypical cadherin Fat3. Deans MR, et al. Neuron, 2011 Sep 8. PMID 21903076, Free PMC Article
  3. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell morphogenesis involved in neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell morphogenesis involved in neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dendrite development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of dendrite development ISO
Inferred from Sequence Orthology
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
involved_in interneuron migration IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within interneuron migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of dendrite development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
  
involved_in retina layer formation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within retina layer formation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protocadherin Fat 3
Names
FAT tumor suppressor homolog 3
Fta3 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001413472.1 → NP_001400401.1  protocadherin Fat 3 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I6ABM1
    Related
    ENSRNOP00000112730.1, ENSRNOT00000173686.1

  2. NM_138544.1 → NP_612553.1  protocadherin Fat 3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_612553.1

    Status: PROVISIONAL

    Source sequence(s)
    AB076401
    UniProtKB/Swiss-Prot
    Q8R508
    Related
    ENSRNOP00000089392.2, ENSRNOT00000118830.2
    Conserved Domains (4) summary
    cd11304
    Location:1048 → 1143
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:285 → 363
    CA; Cadherin repeats
    cd00054
    Location:4097 → 4132
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam02210
    Location:3864 → 3993
    Laminin_G_2; Laminin G domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    20972840..21555679 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080778.2 → XP_038936706.1  protocadherin Fat 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AQQ4
    Related
    ENSRNOP00000096648.1, ENSRNOT00000109404.2
    Conserved Domains (4) summary
    cd11304
    Location:1048 → 1143
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:285 → 363
    CA; Cadherin repeats
    cd00054
    Location:4120 → 4155
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam02210
    Location:3887 → 4016
    Laminin_G_2; Laminin G domain

  2. XM_039080781.2 → XP_038936709.1  protocadherin Fat 3 isoform X3

    UniProtKB/TrEMBL
    F1LMF4
    Conserved Domains (4) summary
    cd11304
    Location:1048 → 1143
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:285 → 363
    CA; Cadherin repeats
    cd00054
    Location:4097 → 4132
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam02210
    Location:3864 → 3993
    Laminin_G_2; Laminin G domain

  3. XM_039080780.2 → XP_038936708.1  protocadherin Fat 3 isoform X2

    Related
    ENSRNOP00000015976.6, ENSRNOT00000015977.7
    Conserved Domains (4) summary
    cd11304
    Location:1048 → 1143
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:285 → 363
    CA; Cadherin repeats
    cd00054
    Location:4120 → 4155
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam02210
    Location:3887 → 4016
    Laminin_G_2; Laminin G domain

  4. XM_039080782.1 → XP_038936710.1  protocadherin Fat 3 isoform X3

    UniProtKB/TrEMBL
    F1LMF4
    Conserved Domains (4) summary
    cd11304
    Location:1048 → 1143
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:285 → 363
    CA; Cadherin repeats
    cd00054
    Location:4097 → 4132
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam02210
    Location:3864 → 3993
    Laminin_G_2; Laminin G domain

  5. XM_039080783.2 → XP_038936711.1  protocadherin Fat 3 isoform X4

    Conserved Domains (3) summary
    cd11304
    Location:2107 → 2203
    Cadherin_repeat; Cadherin tandem repeat domain
    cd00054
    Location:2964 → 2999
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam02210
    Location:2731 → 2860
    Laminin_G_2; Laminin G domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R508.1 GenPept UniProtKB/Swiss-Prot:Q8R508

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