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Ahnak AHNAK nucleoprotein [ Rattus norvegicus (Norway rat) ]

Gene ID: 191572, updated on 4-Jan-2025

Summary

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Official Symbol
Ahnakprovided by RGD
Official Full Name
AHNAK nucleoproteinprovided by RGD
Primary source
RGD:619779
See related
EnsemblRapid:ENSRNOG00000057569 AllianceGenome:RGD:619779
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
UV118; AHNAK 1; RGD1308572
Summary
Predicted to enable S100 protein binding activity; identical protein binding activity; and structural molecule activity conferring elasticity. Predicted to be involved in regulation of RNA splicing and regulation of voltage-gated calcium channel activity. Predicted to be located in several cellular components, including cell-cell contact zone; extracellular exosome; and sarcolemma. Predicted to be part of plasma membrane protein complex. Predicted to be active in costamere and nucleus. Used to study autoimmune disease. Orthologous to human AHNAK (AHNAK nucleoprotein). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 7148.3), Heart (RPKM 4500.7) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ahnak in Genome Data Viewer
Location:
1q43
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (215311289..215400010)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (205882225..205970934)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (225184883..225429638)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483968 Neighboring gene terminal uridylyl transferase 1, U6 snRNA-specific Neighboring gene eukaryotic translation elongation factor 1 gamma Neighboring gene U4 spliceosomal RNA Neighboring gene ribosomal protein L7a, pseudogene 8 Neighboring gene secretoglobin family 1A member 1 Neighboring gene asparaginase and isoaspartyl peptidase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of AHNAK as a novel autoantigen in systemic lupus erythematosus. Sköldberg F, et al. Biochem Biophys Res Commun, 2002 Mar 8. PMID 11866458
  2. Regulated exocytosis: a novel, widely expressed system. Borgonovo B, et al. Nat Cell Biol, 2002 Dec. PMID 12447386
  3. Calcium current in rat cardiomyocytes is modulated by the carboxyl-terminal ahnak domain. Alvarez J, et al. J Biol Chem, 2004 Mar 26. PMID 14722071
  4. Spinal cord injury-induced up-regulation of AHNAK, expressed in cells delineating cystic cavities, and associated with neoangiogenesis. von Boxberg Y, et al. Eur J Neurosci, 2006 Aug. PMID 16930430
  5. The giant protein AHNAK involved in morphogenesis and laminin substrate adhesion of myelinating Schwann cells. Salim C, et al. Glia, 2009 Apr 1. PMID 18837049

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. our results clearly show the implication of AHNAK in myelinating Schwann cell adhesion to laminin, probably via targeting of the dystroglycan-associated receptor complex
    Title: The giant protein AHNAK involved in morphogenesis and laminin substrate adhesion of myelinating Schwann cells.
  2. Results suggest that AHNAK expression is associated with cell types displaying tissue-protective barrier properties, and with neoangiogenesis, following spinal cord injury.
    Title: Spinal cord injury-induced up-regulation of AHNAK, expressed in cells delineating cystic cavities, and associated with neoangiogenesis.
  3. AHNAK has a role in modulating calcium current in rat cardiomyocyte
    Title: Calcium current in rat cardiomyocytes is modulated by the carboxyl-terminal ahnak domain.
  4. Ahnak has a critical role in cardiac Ca(V)1.2 calcium channel function and its beta-adrenergic regulation
    Title: Ahnak is critical for cardiac Ca(V)1.2 calcium channel function and its beta-adrenergic regulation.
  5. The carboxyl-terminal ahnak domain exerts a stabilizing effect on muscle contractility via its interaction with actin of thin filaments.
    Title: The carboxyl-terminal ahnak domain induces actin bundling and stabilizes muscle contraction.
  6. a marker of an extensive form of calcium-induced exocytosis
    Title: Regulated exocytosis: a novel, widely expressed system.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables S100 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables structural molecule activity conferring elasticity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of RNA splicing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell-cell contact zone ISO
Inferred from Sequence Orthology
more info
  
located_in cell-cell contact zone ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in costamere IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in costamere ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
located_in membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of plasma membrane protein complex ISO
Inferred from Sequence Orthology
more info
  
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
neuroblast differentiation-associated protein AHNAK
Names
desmoyokin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398671.1 → NP_001385600.1  neuroblast differentiation-associated protein AHNAK isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A0G2JUA5
    Related
    ENSRNOP00000102284.1, ENSRNOT00000130158.1
    Conserved Domains (3) summary
    COG2911
    Location:2614 → 2920
    TamB; Autotransporter translocation and assembly factor TamB [Intracellular trafficking, secretion, and vesicular transport]
    pfam05109
    Location:4578 → 4776
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl00117
    Location:23 → 91
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

  2. NM_001398672.1 → NP_001385601.1  neuroblast differentiation-associated protein AHNAK isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6HZY6
    Related
    ENSRNOP00000098820.1, ENSRNOT00000134873.1
    Conserved Domains (1) summary
    cl00117
    Location:23 → 91
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    215311289..215400010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017588769.3 → XP_017444258.1  neuroblast differentiation-associated protein AHNAK isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZUE6, A6HZY5, A6HZY6
    Related
    ENSRNOP00000081127.2, ENSRNOT00000112370.2
    Conserved Domains (1) summary
    cl00117
    Location:23 → 91
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

  2. XM_063278638.1 → XP_063134708.1  neuroblast differentiation-associated protein AHNAK isoform X1

    UniProtKB/TrEMBL
    A6HZY6

RNA

  1. XR_005492950.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001191951.1: Suppressed sequence

    Description
    NM_001191951.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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Chemical Information
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