U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

acr-11 AcetylCholine Receptor [ Caenorhabditis elegans ]

Gene ID: 191599, updated on 9-Dec-2024

Summary

Official Symbol
acr-11
Official Full Name
AcetylCholine Receptor
Primary source
WormBase:WBGene00000050
Locus tag
CELE_D2092.3
See related
AllianceGenome:WB:WBGene00000050
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable acetylcholine receptor activity; excitatory extracellular ligand-gated monoatomic ion channel activity; and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in chemical synaptic transmission. Predicted to be located in postsynaptic membrane. Predicted to be part of acetylcholine-gated channel complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; esophagus squamous cell carcinoma; respiratory system cancer (multiple); and schizophrenia. Orthologous to human CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion) and CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit). [provided by Alliance of Genome Resources, Dec 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See acr-11 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (6621624..6624918, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene TetraSPanin family Neighboring gene Translation initiation factor IF-2 Neighboring gene Protein Phosphatase Four Regulatory subunit Neighboring gene ncRNA Neighboring gene C2H2-type domain-containing protein

General gene information

Markers

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in cellular response to stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic transmission, cholinergic IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of acetylcholine-gated channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in synapse IC
Inferred by Curator
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
AcetylCholine Receptor
NP_491906.1
  • Product from WormBase gene class acr;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    6621624..6624918 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_059505.2NP_491906.1  AcetylCholine Receptor [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491906.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91197
    Conserved Domains (3) summary
    TIGR00860
    Location:25456
    LIC; Cation transporter family protein
    pfam02931
    Location:26239
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:246447
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region