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ptr-9 Patched-related protein 9 [ Caenorhabditis elegans ]

Gene ID: 191747, updated on 9-Dec-2024

Summary

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Official Symbol
ptr-9
Official Full Name
Patched-related protein 9
Primary source
WormBase:WBGene00004223
Locus tag
CELE_F54G8.5
See related
AllianceGenome:WB:WBGene00004223
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in molting cycle. Predicted to be located in membrane. Predicted to be active in cytoplasmic vesicle membrane and plasma membrane. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human PTCHD1 (patched domain containing 1); PTCHD3 (patched domain containing 3 (gene/pseudogene)); and PTCHD4 (patched domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ptr-9 in Genome Data Viewer
Location:
chromosome: III
Exon count:
13
Sequence:
Chromosome: III; NC_003281.10 (9157204..9161653, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene RING finger protein nhl-1;RING-type domain-containing protein Neighboring gene Protein irld-34 Neighboring gene ncRNA Neighboring gene putative diacylglycerol kinase 3 Neighboring gene Integrin alpha ina-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The function and expansion of the Patched- and Hedgehog-related homologs in C. elegans. Zugasti O, et al. Genome Res, 2005 Oct. PMID 16204193, Free PMC Article
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in molting cycle, collagen and cuticulin-based cuticle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in molting cycle, collagen and cuticulin-based cuticle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasmic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Patched-related protein 9
NP_499030.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    9157204..9161653 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_066629.6 → NP_499030.2  Patched-related protein 9 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499030.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q03602
    Conserved Domains (2) summary
    pfam02460
    Location:52 → 817
    Patched; Patched family
    pfam12349
    Location:288 → 439
    Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03602.2

Gene LinkOut

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