tkr-1 putative G-protein coupled receptor tkr-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: tkr-1
Official Full Name: putative G-protein coupled receptor tkr-1
Primary source: WormBase:WBGene00006576
Locus tag: CELE_C38C10.1
See related: AllianceGenome:WB:WBGene00006576
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable tachykinin receptor activity. Predicted to be involved in tachykinin receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in ADEsoL; ADEsoR; PDEsoL; and PDEsoR. Human ortholog(s) of this gene implicated in developmental disorder of mental health; exercise-induced bronchoconstriction; and hypogonadotropic hypogonadism 11 with or without anosmia. Orthologous to human TACR1 (tachykinin receptor 1) and TACR3 (tachykinin receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See tkr-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 8

Sequence:: Chromosome: III; NC_003281.10 (9383796..9387704)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C38C10.3 (e-PCR)
- UniSTS:306397

C38C10.1 (e-PCR)
- UniSTS:313831

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables tachykinin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables tachykinin receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in tachykinin receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative G-protein coupled receptor tkr-1

NP_499064.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

9383796..9387704

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066663.6 → NP_499064.2 putative G-protein coupled receptor tkr-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499064.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q03566

Conserved Domains (2) summary

pfam00001
Location:60 → 315

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:58 → 330

7tm_4; Olfactory receptor