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Akr1d1 aldo-keto reductase family 1, member D1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 192242, updated on 4-Jan-2025

Summary

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Official Symbol
Akr1d1provided by RGD
Official Full Name
aldo-keto reductase family 1, member D1provided by RGD
Primary source
RGD:620752
See related
EnsemblRapid:ENSRNOG00000013004 AllianceGenome:RGD:620752
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables 3-oxo-5-beta-steroid 4-dehydrogenase activity. Predicted to be involved in digestion and steroid metabolic process. Predicted to act upstream of or within bile acid biosynthetic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 2. Orthologous to human AKR1D1 (aldo-keto reductase family 1 member D1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward (RPKM 2347.4) See more
Orthologs
human mouse all
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Genomic context

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See Akr1d1 in Genome Data Viewer
Location:
4q23
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (67121288..67154543)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (66154246..66187505)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (65110706..65143930)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase, iota Neighboring gene cAMP responsive element binding protein 3-like 2 Neighboring gene uncharacterized LOC134486755 Neighboring gene high-mobility group box 1, pseudogene 18 Neighboring gene tripartite motif-containing 24

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of the 37-kd rat liver protein that forms an acetaldehyde adduct in vivo as delta 4-3-ketosteroid 5 beta-reductase. Zhu Y, et al. Hepatology, 1996 Jan. PMID 8550030
  2. delta 4-3-Oxosteroid 5 beta-reductase. Structure and function. Onishi Y, et al. Biol Chem Hoppe Seyler, 1991 Dec. PMID 1789929
  3. Molecular cloning and sequence analysis of cDNA encoding delta 4-3-ketosteroid 5 beta-reductase of rat liver. Onishi Y, et al. FEBS Lett, 1991 Jun 3. PMID 1710579
  4. Cloning and expression of cDNA of human delta 4-3-oxosteroid 5 beta-reductase and substrate specificity of the expressed enzyme. Kondo KH, et al. Eur J Biochem, 1994 Jan 15. PMID 7508385
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3-oxo-5-beta-steroid 4-dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables Delta4-3-oxosteroid 5beta-reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables aldose reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ketosteroid monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables steroid dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in C21-steroid hormone metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in C21-steroid hormone metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in androgen metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in androgen metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in androgen metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in bile acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within bile acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in bile acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in bile acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cholesterol catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cholesterol catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in digestion IEA
Inferred from Electronic Annotation
more info
  
involved_in digestion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
aldo-keto reductase family 1 member D1
Names
3-oxo-5-beta-steroid 4-dehydrogenase
aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
delta(4)-3-ketosteroid 5-beta-reductase
delta(4)-3-oxosteroid 5-beta-reductase
NP_620239.2
XP_006236347.1
XP_038962921.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138884.2 → NP_620239.2  aldo-keto reductase family 1 member D1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    P31210
    UniProtKB/TrEMBL
    A0A8I5ZSN6, A6IEQ7
    Related
    ENSRNOP00000080261.1, ENSRNOT00000103598.2
    Conserved Domains (1) summary
    cd19109
    Location:15 → 321
    AKR_AKR1D1-3; AKR1D family of aldo-keto reductase (AKR)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    67121288..67154543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039106993.2 → XP_038962921.1  aldo-keto reductase family 1 member D1 isoform X2

    UniProtKB/Swiss-Prot
    P31210
    Related
    ENSRNOP00000111180.1, ENSRNOT00000161889.1
    Conserved Domains (1) summary
    cl00470
    Location:15 → 295
    AKR_SF; Aldo-keto reductase (AKR) superfamily

  2. XM_006236285.3 → XP_006236347.1  aldo-keto reductase family 1 member D1 isoform X1

    UniProtKB/Swiss-Prot
    P31210
    UniProtKB/TrEMBL
    A0A0G2KAV5
    Related
    ENSRNOP00000075542.1, ENSRNOT00000083672.3
    Conserved Domains (2) summary
    COG0656
    Location:28 → 297
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:26 → 289
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P31210.1 GenPept UniProtKB/Swiss-Prot:P31210

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