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Gpr149 G protein-coupled receptor 149 [ Rattus norvegicus (Norway rat) ]

Gene ID: 192251, updated on 27-Nov-2024

Summary

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Official Symbol
Gpr149provided by RGD
Official Full Name
G protein-coupled receptor 149provided by RGD
Primary source
RGD:619890
See related
EnsemblRapid:ENSRNOG00000014793 AllianceGenome:RGD:619890
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ieda
Summary
Predicted to enable G protein-coupled receptor activity and neuropeptide binding activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to act upstream of or within antral ovarian follicle growth; negative regulation of ovulation; and preantral ovarian follicle growth. Predicted to be active in neuron projection and plasma membrane. Orthologous to human GPR149 (G protein-coupled receptor 149). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 13.2), Testes (RPKM 3.3) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gpr149 in Genome Data Viewer
Location:
2q31
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (149059333..149130798, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (146909710..146981924, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (152838836..152912027, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 26 Neighboring gene uncharacterized LOC134485922 Neighboring gene uncharacterized LOC120100834 Neighboring gene DEAH-box helicase 36 Neighboring gene RNA, U6 small nuclear 1286 Neighboring gene uncharacterized LOC134485788

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel seven transmembrane receptor induced during the early steps of astrocyte differentiation identified by differential expression. De Smet C, et al. J Neurochem, 2002 May. PMID 12065666
  2. Deletion of the novel oocyte-enriched gene, Gpr149, leads to increased fertility in mice. Edson MA, et al. Endocrinology, 2010 Jan. PMID 19887567, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within antral ovarian follicle growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of ovulation ISO
Inferred from Sequence Orthology
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within preantral ovarian follicle growth ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 149
Names
induced early in differentiating astrocytes gene protein
orphan seven transmembrane receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433874.1 → NP_001420803.1  probable G-protein coupled receptor 149 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002

  2. NM_001433876.1 → NP_001420805.1  probable G-protein coupled receptor 149 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002

  3. NM_138891.2 → NP_620246.1  probable G-protein coupled receptor 149 isoform 1

    See identical proteins and their annotated locations for NP_620246.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q924Y8
    UniProtKB/TrEMBL
    A6JVN3
    Related
    ENSRNOP00000019929.2, ENSRNOT00000019929.5
    Conserved Domains (1) summary
    pfam00001
    Location:54 → 209
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RNA

  1. NR_197598.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    149059333..149130798 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101674.2 → XP_038957602.1  probable G-protein coupled receptor 149 isoform X1

    Conserved Domains (1) summary
    cd15011
    Location:35 → 372
    7tmA_GPR149; G protein-coupled receptor 149, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q924Y8.1 GenPept UniProtKB/Swiss-Prot:Q924Y8

Gene LinkOut

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