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Slc25a36 solute carrier family 25, member 36 [ Mus musculus (house mouse) ]

Gene ID: 192287, updated on 27-Nov-2024

Summary

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Official Symbol
Slc25a36provided by MGI
Official Full Name
solute carrier family 25, member 36provided by MGI
Primary source
MGI:MGI:1924909
See related
Ensembl:ENSMUSG00000032449 AllianceGenome:MGI:1924909
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C330005L02Rik
Summary
Predicted to enable pyrimidine nucleotide transmembrane transporter activity. Predicted to be involved in mitochondrial genome maintenance; pyrimidine nucleotide import into mitochondrion; and regulation of mitochondrial membrane potential. Located in mitochondrion. Is expressed in embryo. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 8. Orthologous to human SLC25A36 (solute carrier family 25 member 36). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 20.5), CNS E18 (RPKM 14.1) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Slc25a36 in Genome Data Viewer
Location:
9 E3.3; 9 50.84 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (96957014..96993094, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (97075281..97111041, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene casein kinase 1, alpha 1 pseudogene Neighboring gene predicted gene, 19325 Neighboring gene STARR-seq mESC enhancer starr_24985 Neighboring gene STARR-positive B cell enhancer ABC_E1392 Neighboring gene STARR-seq mESC enhancer starr_24987 Neighboring gene STARR-seq mESC enhancer starr_24989 Neighboring gene ribosomal protein L7A, pseudogene 10 Neighboring gene STARR-seq mESC enhancer starr_24990 Neighboring gene pyruvate kinase, muscle pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Slc25a36 modulates pluripotency of mouse embryonic stem cells by regulating mitochondrial function and glutathione level. Xin Y, et al. Biochem J, 2019 Jun 11. PMID 31036718
  2. Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevisiae. Hildyard JC, et al. Biochem J, 2003 Sep 15. PMID 12887330, Free PMC Article
  3. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article
  4. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917
  5. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables pyrimidine nucleotide transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyrimidine nucleotide transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables pyrimidine nucleotide transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mitochondrial genome maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial genome maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial genome maintenance ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in pyrimidine nucleotide import into mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyrimidine nucleotide transport ISO
Inferred from Sequence Orthology
more info
  
involved_in pyrimidine nucleotide transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrial membrane potential ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
solute carrier family 25 member 36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138756.4 → NP_620095.1  solute carrier family 25 member 36

    See identical proteins and their annotated locations for NP_620095.1

    Status: PROVISIONAL

    Source sequence(s)
    AC121121
    Consensus CDS
    CCDS23420.1
    UniProtKB/Swiss-Prot
    Q922G0
    Related
    ENSMUSP00000082302.5, ENSMUST00000085206.11
    Conserved Domains (2) summary
    PTZ00169
    Location:5 → 290
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:2 → 113
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    96957014..96993094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242678.4 → XP_011240980.1  solute carrier family 25 member 36 isoform X2

    Conserved Domains (1) summary
    pfam00153
    Location:156 → 245
    Mito_carr; Mitochondrial carrier protein

  2. XM_006510870.5 → XP_006510933.1  solute carrier family 25 member 36 isoform X1

    Conserved Domains (1) summary
    pfam00153
    Location:156 → 245
    Mito_carr; Mitochondrial carrier protein

  3. XM_006510871.3 → XP_006510934.1  solute carrier family 25 member 36 isoform X3

    Conserved Domains (1) summary
    pfam00153
    Location:54 → 150
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q922G0.1 GenPept UniProtKB/Swiss-Prot:Q922G0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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