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smc4 structural maintenance of chromosomes 4 [ Danio rerio (zebrafish) ]

Gene ID: 192332, updated on 4-Jan-2025

Summary

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Official Symbol
smc4provided by ZNC
Official Full Name
structural maintenance of chromosomes 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-020419-21
See related
Ensembl:ENSDARG00000038882 AllianceGenome:ZFIN:ZDB-GENE-020419-21
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb788; smc4l1; fb99b10; chunp6901; wu:fb99b10
Summary
Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to be involved in mitotic chromosome condensation. Predicted to act upstream of or within chromosome organization. Predicted to be located in chromosome and nucleus. Predicted to be part of condensin complex. Is expressed in several structures, including digestive system; nervous system; optic cup; otic vesicle; and pectoral fin. Orthologous to human SMC4 (structural maintenance of chromosomes 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See smc4 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (1534625..1573130)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (1569716..1608221)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene karyopherin alpha 4 (importin alpha 3) Neighboring gene chromosome 15 C3orf80 homolog Neighboring gene intraflagellar transport 80 homolog (Chlamydomonas) Neighboring gene microRNA 15c Neighboring gene microRNA 16a Neighboring gene tripartite motif containing 59 Neighboring gene nanor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The Zebrafish Meiotic Cohesin Complex Protein Smc1b Is Required for Key Events in Meiotic Prophase I. Islam KN, et al. Front Cell Dev Biol, 2021. PMID 34434933, Free PMC Article
  2. Expression of cohesin and condensin genes during zebrafish development supports a non-proliferative role for cohesin. Mönnich M, et al. Gene Expr Patterns, 2009 Dec. PMID 19723591
  3. Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development. Golling G, et al. Nat Genet, 2002 Jun. PMID 12006978
  4. Differential recruitment of co-regulatory proteins to the human estrogen receptor 1 in response to xenoestrogens. Smith LC, et al. Comp Biochem Physiol Part D Genomics Proteomics, 2016 Sep. PMID 27156127, Free PMC Article
  5. Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Recher G, et al. Development, 2013 Dec. PMID 24198278

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromosome organization IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
part_of condensin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
structural maintenance of chromosomes protein 4
Names
MC4 structural maintenance of chromosomes 4-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173253.2 → NP_775360.2  structural maintenance of chromosomes protein 4

    Status: VALIDATED

    Source sequence(s)
    CR478286, EB930997, EB935660, EH586089, EH591853, EH603521, EH609354
    UniProtKB/TrEMBL
    A0A8N1TUC6, E7FGC2
    Related
    ENSDARP00000108838.2, ENSDART00000130413.4
    Conserved Domains (5) summary
    cd03274
    Location:81 → 240
    ABC_SMC4_euk; ATP-binding cassette domain of eukaryotic SMC4 proteins
    smart00968
    Location:612 → 726
    SMC_hinge; SMC proteins Flexible Hinge Domain
    pfam02463
    Location:82 → 1273
    SMC_N; RecF/RecN/SMC N terminal domain
    cl00459
    Location:866 → 1025
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl23887
    Location:274 → 435
    DUF4349; Domain of unknown function (DUF4349)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    1534625..1573130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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