U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gmpr2 guanosine monophosphate reductase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 192357, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Gmpr2provided by RGD
Official Full Name
guanosine monophosphate reductase 2provided by RGD
Primary source
RGD:628875
See related
EnsemblRapid:ENSRNOG00000020216 AllianceGenome:RGD:628875
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GMP reductase activity. Predicted to be involved in GMP metabolic process. Predicted to be part of GMP reductase complex. Orthologous to human GMPR2 (guanosine monophosphate reductase 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 123.7), Adrenal (RPKM 109.0) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Gmpr2 in Genome Data Viewer
Location:
15p13
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (33135455..33144923)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (29165421..29175933)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34352857..34362074)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene testis-specific serine kinase 4 Neighboring gene magnesium-dependent phosphatase 1 Neighboring gene NEDD8 ubiquitin like modifier Neighboring gene TERF1 interacting nuclear factor 2 Neighboring gene transglutaminase 1 Neighboring gene Rab geranylgeranyltransferase subunit alpha

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes. Patton GC, et al. Nat Chem Biol, 2011 Oct 30. PMID 22037469, Free PMC Article
  2. Cloning and functional characterization of GMPR2, a novel human guanosine monophosphate reductase, which promotes the monocytic differentiation of HL-60 leukemia cells. Zhang J, et al. J Cancer Res Clin Oncol, 2003 Feb. PMID 12669231
  3. Reaction mechanism and specificity of human GMP reductase. Substrates, inhibitors, activators, and inactivators. Spector T, et al. J Biol Chem, 1979 Apr 10. PMID 218932
  4. NADPH-dependent GMP reductase isoenzyme of human (GMPR2). Expression, purification, and kinetic properties. Deng Y, et al. Int J Biochem Cell Biol, 2002 Sep. PMID 12009299
  5. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC108877

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GMP reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GMP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in purine nucleobase metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of GMP reductase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
GMP reductase 2
Names
guanosine monophosphate reductase isolog
NP_001013054.1
NP_001400700.1
NP_001400701.1
XP_006251988.1
XP_063130029.1
XP_063130030.1
XP_063130031.1
XP_063130033.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013036.1 → NP_001013054.1  GMP reductase 2 isoform 1

    See identical proteins and their annotated locations for NP_001013054.1

    Status: VALIDATED

    Source sequence(s)
    BC089848
    UniProtKB/TrEMBL
    Q5FVP6
    Conserved Domains (1) summary
    cd00381
    Location:10 → 280
    IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...

  2. NM_001413771.1 → NP_001400700.1  GMP reductase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A6KH36
    Related
    ENSRNOP00000070108.3, ENSRNOT00000084554.3

  3. NM_001413772.1 → NP_001400701.1  GMP reductase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    Related
    ENSRNOP00000060006.2, ENSRNOT00000067150.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    33135455..33144923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273960.1 → XP_063130030.1  GMP reductase 2 isoform X1

    UniProtKB/TrEMBL
    A6KH36

  2. XM_006251926.5 → XP_006251988.1  GMP reductase 2 isoform X2

    Conserved Domains (1) summary
    cd00381
    Location:10 → 280
    IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...

  3. XM_063273959.1 → XP_063130029.1  GMP reductase 2 isoform X1

    UniProtKB/TrEMBL
    A6KH36

  4. XM_063273961.1 → XP_063130031.1  GMP reductase 2 isoform X2

  5. XM_063273963.1 → XP_063130033.1  GMP reductase 2 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous