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CG5986 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 192506, updated on 9-Dec-2024

Summary

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Official Symbol
CG5986provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0043455
Locus tag
Dmel_CG5986
See related
AllianceGenome:FB:FBgn0043455
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:LP03871; Dmel\CG5986
Summary
Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U2-type prespliceosome. Is expressed in organism; wing hinge primordium; and wing pouch. Orthologous to human SDE2 (SDE2 telomere maintenance homolog). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG5986 in Genome Data Viewer
Location:
95D10-95D10; 3-82 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24047790..24049168)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19873512..19874890)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Methyltransferase like 3 Neighboring gene Mitochondrial Rho Neighboring gene spastin Neighboring gene Rox8 Neighboring gene Autophagy-related 6 Neighboring gene Phosphatidylserine decarboxylase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A gain-of-function screen for genes that affect the development of the Drosophila adult external sensory organ. Abdelilah-Seyfried S, et al. Genetics, 2000 Jun. PMID 10835395, Free PMC Article
  2. Impaired retrograde transport by the Dynein/Dynactin complex contributes to Tau-induced toxicity. Butzlaff M, et al. Hum Mol Genet, 2015 Jul 1. PMID 25794683
  3. Genetic modifier screens on Hairless gain-of-function phenotypes reveal genes involved in cell differentiation, cell growth and apoptosis in Drosophila melanogaster. Müller D, et al. Genetics, 2005 Nov. PMID 16118195, Free PMC Article
  4. An RNAi-mediated screen identifies novel targets for next-generation antiepileptic drugs based on increased expression of the homeostatic regulator pumilio. Lin WH, et al. J Neurogenet, 2018 Mar-Jun. PMID 29718742, Free PMC Article
  5. Genetic annotation of gain-of-function screens using RNA interference and in situ hybridization of candidate genes in the Drosophila wing. Molnar C, et al. Genetics, 2012 Oct. PMID 22798488, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of U2-type prespliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG5986-PA
CG5986-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24047790..24049168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142950.2 → NP_651207.1  uncharacterized protein Dmel_CG5986, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651207.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VCE2
    Related
    FBpp0083920
    Conserved Domains (1) summary
    cl00155
    Location:58 → 113
    UBQ; Ubiquitin-like proteins

  2. NM_001275970.1 → NP_001262899.1  uncharacterized protein Dmel_CG5986, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262899.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VCE2
    Conserved Domains (1) summary
    cl00155
    Location:58 → 113
    UBQ; Ubiquitin-like proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VCE2 Q9VCE2

Gene LinkOut

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