U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ndf Nucleosome-destabilizing factor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 192507, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
Ndfprovided by FlyBase
Official Full Name
Nucleosome-destabilizing factorprovided by FlyBase
Primary source
FLYBASE:FBgn0043456
Locus tag
Dmel_CG4747
See related
AllianceGenome:FB:FBgn0043456
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:GH19401; BEST:LD22483; BEST:LD29743; CG4747; Dmel\CG4747; Dm_AI388468; dNDF; LD29743; NDF
Summary
Enables DNA binding activity and nucleosome binding activity. Involved in sex-chromosome dosage compensation and transcription elongation-coupled chromatin remodeling. Located in polytene chromosome interband. Is expressed in adult head; adult heart; and organism. Orthologous to human GLYR1 (glyoxylate reductase 1 homolog). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Ndf in Genome Data Viewer
Location:
30F5-30F5; 2-38 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10003832..10008889)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10003832..10008889)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR13130 Neighboring gene big brain Neighboring gene uncharacterized protein Neighboring gene Sister of Yb Neighboring gene antisense RNA:CR44873 Neighboring gene Translocation protein 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation? Stec I, et al. FEBS Lett, 2000 May 4. PMID 10802047
  2. NDF, a nucleosome-destabilizing factor that facilitates transcription through nucleosomes. Fei J, et al. Genes Dev, 2018 May 1. PMID 29759984, Free PMC Article
  3. Dynamics of nuclear matrix proteome during embryonic development in Drosophila melanogaster. Varma P, et al. J Biosci, 2011 Aug. PMID 21799256
  4. Chromatin proteins captured by ChIP-mass spectrometry are linked to dosage compensation in Drosophila. Wang CI, et al. Nat Struct Mol Biol, 2013 Feb. PMID 23295261, Free PMC Article
  5. The gene search system. A method for efficient detection and rapid molecular identification of genes in Drosophila melanogaster. Toba G, et al. Genetics, 1999 Feb. PMID 9927464, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CG4747 and Set2 function together to facilitate targeting of the male-specific lethal complex to active genes.
    Title: Chromatin proteins captured by ChIP-mass spectrometry are linked to dosage compensation in Drosophila.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in sex-chromosome dosage compensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription elongation-coupled chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription elongation-coupled chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in polytene chromosome interband IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Nucleosome-destabilizing factor
Names
CG4747-PA
CG4747-PB
CG4747-PC
Ndf-PA
Ndf-PB
Ndf-PC
nucleosome-destabilizing factor
NP_001188767.1
NP_001285791.1
NP_609336.3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10003832..10008889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001201838.2 → NP_001188767.1  Nucleosome-destabilizing factor, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188767.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MRG2
    Conserved Domains (4) summary
    cd05836
    Location:20 → 106
    N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
    COG2084
    Location:319 → 597
    MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
    pfam03446
    Location:316 → 477
    NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase
    pfam14833
    Location:481 → 597
    NAD_binding_11; NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase

  2. NM_135492.5 → NP_609336.3  Nucleosome-destabilizing factor, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609336.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T079, Q9VL51
    UniProtKB/TrEMBL
    X2JDP6
    Related
    FBpp0079520
    Conserved Domains (3) summary
    cd05836
    Location:20 → 106
    N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
    COG2084
    Location:319 → 596
    MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
    PRK00708
    Location:176 → 267
    PRK00708; twin-arginine translocase subunit TatB

  3. NM_001298862.1 → NP_001285791.1  Nucleosome-destabilizing factor, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285791.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8T079, Q9VL51
    UniProtKB/TrEMBL
    X2JDP6
    Conserved Domains (3) summary
    cd05836
    Location:20 → 106
    N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
    COG2084
    Location:319 → 596
    MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]
    PRK00708
    Location:176 → 267
    PRK00708; twin-arginine translocase subunit TatB
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9MRG2 M9MRG2
Q8T079.1 Q8T079
X2JDP6 X2JDP6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools