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CG12084 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 192509, updated on 9-Dec-2024

Summary

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Official Symbol
CG12084provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0043458
Locus tag
Dmel_CG12084
See related
AllianceGenome:FB:FBgn0043458
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:LD02105; Dmel\CG12084; LD02105
Summary
Predicted to be part of Cul2-RING ubiquitin ligase complex. Is expressed in germline cell; organism; pole plasm; and primordial germ cell. Orthologous to human ZER1 (zyg-11 related cell cycle regulator). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG12084 in Genome Data Viewer
Location:
62A2-62A2; 3-0.5 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1490951..1496643, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1490951..1496643, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene stem cell tumor Neighboring gene ncRNA Neighboring gene small non-coding RNA:CR43701 Neighboring gene antisense RNA:CR45812 Neighboring gene small Cajal body-specific RNA : MeU2-48 Neighboring gene half pint Neighboring gene Puromycin sensitive aminopeptidase Neighboring gene cueball

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fat-regulated adaptor protein Dlish binds the growth suppressor Expanded and controls its stability and ubiquitination. Wang X, et al. Proc Natl Acad Sci U S A, 2019 Jan 22. PMID 30606799, Free PMC Article
  2. An overexpression screen in Drosophila for genes that restrict growth or cell-cycle progression in the developing eye. Tseng AS, et al. Genetics, 2002 Sep. PMID 12242236, Free PMC Article
  3. A gain-of-function screen for genes that affect the development of the Drosophila adult external sensory organ. Abdelilah-Seyfried S, et al. Genetics, 2000 Jun. PMID 10835395, Free PMC Article
  4. Circulating glucose levels inversely correlate with Drosophila larval feeding through insulin signaling and SLC5A11. Ugrankar R, et al. Commun Biol, 2018. PMID 30271990, Free PMC Article
  5. A misexpression study examining dorsal thorax formation in Drosophila melanogaster. Peña-Rangel MT, et al. Genetics, 2002 Mar. PMID 11901120, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul2-RING ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG12084-PA
CG12084-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1490951..1496643 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274328.1 → NP_001261257.1  uncharacterized protein Dmel_CG12084, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261257.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PBH9
    Conserved Domains (2) summary
    cd00020
    Location:535 → 643
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00034
    Location:110 → 135
    LRR_AMN1; leucine-rich repeat [structural motif]

  2. NM_138268.2 → NP_612112.1  uncharacterized protein Dmel_CG12084, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_612112.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W0E8
    Related
    FBpp0072595
    Conserved Domains (2) summary
    cd00020
    Location:535 → 628
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00034
    Location:110 → 135
    LRR_AMN1; leucine-rich repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PBH9 M9PBH9
Q9W0E8.2 Q9W0E8

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