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Prokr2 prokineticin receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 192649, updated on 27-Nov-2024

Summary

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Official Symbol
Prokr2provided by RGD
Official Full Name
prokineticin receptor 2provided by RGD
Primary source
RGD:708445
See related
EnsemblRapid:ENSRNOG00000082181 AllianceGenome:RGD:708445
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gpr73l1
Summary
Enables G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and circadian rhythm. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 3 with or without anosmia. Orthologous to human PROKR2 (prokineticin receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 11.1), Spleen (RPKM 2.3) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Prokr2 in Genome Data Viewer
Location:
3q36
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (140077629..140092327, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (119624738..119639442, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (125006180..125021020, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene CDP-diacylglycerol synthase 2 Neighboring gene uncharacterized LOC120101670 Neighboring gene glycerophosphocholine phosphodiesterase 1 Neighboring gene uncharacterized LOC102552951

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterization of Prokineticin receptor 2 splicing variant and its modulation in an animal model of Alzheimer's disease. Lattanzi R, et al. Neuropeptides, 2019 Feb. PMID 30553543
  2. Prokineticin 2 potentiates acid-sensing ion channel activity in rat dorsal root ganglion neurons. Qiu CY, et al. J Neuroinflammation, 2012 May 29. PMID 22642848, Free PMC Article
  3. Distinct localization of prokineticin 2 and prokineticin receptor 2 mRNAs in the rat suprachiasmatic nucleus. Masumoto KH, et al. Eur J Neurosci, 2006 Jun. PMID 16819985
  4. PROKR2 missense mutations associated with Kallmann syndrome impair receptor signalling activity. Monnier C, et al. Hum Mol Genet, 2009 Jan 1. PMID 18826963, Free PMC Article
  5. Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors. Masuda Y, et al. Biochem Biophys Res Commun, 2002 Apr 26. PMID 12054613

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study identified a prokineticin receptor 2 (PKR2) splice variant, which lacking the second exon gives rise to a protein comprising only four transmembrane elements, denominated TM 4-7.
    Title: Identification and characterization of Prokineticin receptor 2 splicing variant and its modulation in an animal model of Alzheimer's disease.
  2. PK2 increases the activity of acid-sensing ion channels via the PK2 receptor and protein kinase C-dependent signal pathways in rat primary sensory neurons.
    Title: Prokineticin 2 potentiates acid-sensing ion channel activity in rat dorsal root ganglion neurons.
  3. The results of this study suggested an intrinsic PK2 neurotransmission and functionally distinct roles for PKR2-expressing neurons in the SCN.
    Title: Distinct localization of prokineticin 2 and prokineticin receptor 2 mRNAs in the rat suprachiasmatic nucleus.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables neuropeptide Y receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in circadian rhythm IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in circadian rhythm IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within circadian rhythm ISO
Inferred from Sequence Orthology
more info
  
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
prokineticin receptor 2
Names
G protein-coupled receptor 73-like 1
G protein-coupled receptor I5E
PK-R2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138978.2 → NP_620434.2  prokineticin receptor 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q8R415
    UniProtKB/TrEMBL
    A6HQG2, G3V8W3
    Related
    ENSRNOP00000105365.1, ENSRNOT00000170624.1
    Conserved Domains (1) summary
    cd15204
    Location:92 → 382
    7tmA_prokineticin-R; prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    140077629..140092327 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104229.2 → XP_038960157.1  prokineticin receptor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8R415
    UniProtKB/TrEMBL
    A6HQG2, G3V8W3
    Conserved Domains (1) summary
    cd15204
    Location:92 → 382
    7tmA_prokineticin-R; prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R415.2 GenPept UniProtKB/Swiss-Prot:Q8R415

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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