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Pla2g15 phospholipase A2, group XV [ Mus musculus (house mouse) ]

Gene ID: 192654, updated on 27-Nov-2024

Summary

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Official Symbol
Pla2g15provided by MGI
Official Full Name
phospholipase A2, group XVprovided by MGI
Primary source
MGI:MGI:2178076
See related
Ensembl:ENSMUSG00000031903 AllianceGenome:MGI:2178076
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ACS; LLPL; Lpla2; Lypla3
Summary
Enables acylglycerol O-acyltransferase activity; calcium-independent phospholipase A2 activity; and phospholipase A1 activity. Involved in ceramide metabolic process and glycerolipid metabolic process. Located in extracellular space and lysosome. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human PLA2G15 (phospholipase A2 group XV). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in spleen adult (RPKM 14.2), subcutaneous fat pad adult (RPKM 13.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pla2g15 in Genome Data Viewer
Location:
8 D3; 8 53.1 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106876986..106891350)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (106150354..106164718)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:108636517-108636718 Neighboring gene RIKEN cDNA 1810019D21 gene Neighboring gene STARR-positive B cell enhancer ABC_E9739 Neighboring gene epithelial splicing regulatory protein 2 Neighboring gene STARR-positive B cell enhancer mm9_chr8:108674075-108674376 Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 Neighboring gene solute carrier family 7, member 6 opposite strand

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structure and function of lysosomal phospholipase A2: identification of the catalytic triad and the role of cysteine residues. Hiraoka M, et al. J Lipid Res, 2005 Nov. PMID 16106046
  2. Role for lysosomal phospholipase A2 in iNKT cell-mediated CD1d recognition. Paduraru C, et al. Proc Natl Acad Sci U S A, 2013 Mar 26. PMID 23493550, Free PMC Article
  3. The secretion and uptake of lysosomal phospholipase A2 by alveolar macrophages. Abe A, et al. J Immunol, 2008 Dec 1. PMID 19017977
  4. Lysosomal phospholipase A2 is selectively expressed in alveolar macrophages. Abe A, et al. J Biol Chem, 2004 Oct 8. PMID 15294901
  5. Positional specificity of lysosomal phospholipase A2. Abe A, et al. J Lipid Res, 2006 Oct. PMID 16837646

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Esterification of side-chain oxysterols by lysosomal phospholipase A2.
    Title: Esterification of side-chain oxysterols by lysosomal phospholipase A2.
  2. LPLA2 plays a role in the generation of CD1d complexes with thymic lipids required for the normal selection and maturation of iNKT cells.
    Title: Role for lysosomal phospholipase A2 in iNKT cell-mediated CD1d recognition.
  3. The secretion and uptake of lysosomal phospholipase A2 by alveolar macrophages
    Title: The secretion and uptake of lysosomal phospholipase A2 by alveolar macrophages.
  4. activity is anti-atherogenic and indicate that the regulation of this enzyme might be a novel drug target for the treatment of atherosclerosis
    Title: Loss of lysophospholipase 3 increases atherosclerosis in apolipoprotein E-deficient mice.
  5. LPLA2 may be a major enzyme of pulmonary surfactant phospholipid degradation by alveolar macrophages
    Title: Lysosomal phospholipase A2 is selectively expressed in alveolar macrophages.
  6. identification of the catalytic triad and the role of cysteine residues in lysosomal phospholipase A2
    Title: Structure and function of lysosomal phospholipase A2: identification of the catalytic triad and the role of cysteine residues.
  7. Lpla2 has broad positional specificity for the sn-1 and sn-2 acyl groups in phosphatidylcholine and phosphatidylethanolamine
    Title: Positional specificity of lysosomal phospholipase A2.
  8. A deficiency of lysosomal phospholipase A2 results in foam cell formation, surfactant lipid accumulation, splenomegaly, and phospholipidosis in mice.
    Title: Lysosomal phospholipase A2 and phospholipidosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables acylglycerol O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium-dependent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium-independent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-independent phospholipase A2 activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium-independent phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables lysophospholipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylserine 1-acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase A1 activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipase A1 activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in ceramide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ceramide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ceramide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ceramide metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in diacylglycerol biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerophospholipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycerophospholipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylcholine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylcholine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylcholine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylcholine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylethanolamine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylethanolamine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylglycerol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylglycerol metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidylserine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylserine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
lysosomal phospholipase A and acyltransferase; phospholipase A2 group XV
Names
1-O-acylceramide synthase
LCAT-like lysophospholipase
group XV phospholipase A2
lysophospholipase 3
lysosomal phospholipase A2
NP_001344248.1
NP_598553.1
XP_036009728.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357319.1 → NP_001344248.1  lysosomal phospholipase A and acyltransferase isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC133195, AK028614, BM226964
    Consensus CDS
    CCDS90455.1
    UniProtKB/TrEMBL
    A0A1D5RLZ5
    Related
    ENSMUSP00000148565.2, ENSMUST00000212963.2
    Conserved Domains (1) summary
    cl21494
    Location:84 → 167
    Abhydrolase; alpha/beta hydrolases

  2. NM_133792.3 → NP_598553.1  lysosomal phospholipase A and acyltransferase isoform 1 precursor

    See identical proteins and their annotated locations for NP_598553.1

    Status: VALIDATED

    Source sequence(s)
    AC133195, AK085194, BM226964
    Consensus CDS
    CCDS22630.1
    UniProtKB/Swiss-Prot
    Q3TCB1, Q3U303, Q8VEB4
    Related
    ENSMUSP00000034377.7, ENSMUST00000034377.8
    Conserved Domains (1) summary
    cl21494
    Location:84 → 396
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106876986..106891350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153835.1 → XP_036009728.1  phospholipase A2 group XV isoform X1

    Conserved Domains (1) summary
    cl21494
    Location:45 → 357
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VEB4.1 GenPept UniProtKB/Swiss-Prot:Q8VEB4

Gene LinkOut

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