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Rfpl4 ret finger protein-like 4 [ Mus musculus (house mouse) ]

Gene ID: 192658, updated on 13-Jan-2025

Summary

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Official Symbol
Rfpl4provided by MGI
Official Full Name
ret finger protein-like 4provided by MGI
Primary source
MGI:MGI:2149590
See related
Ensembl:ENSMUSG00000035191 AllianceGenome:MGI:2149590
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rfpl4a; D7Ertd486e
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response; positive regulation of cysteine-type endopeptidase activity; and regulation of gene expression. Located in cytoplasm and female germ cell nucleus. Is expressed in bladder; central nervous system; and ureter. Orthologous to several human genes including RFPL4A (ret finger protein like 4A). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward ovary adult (RPKM 1.2) See more
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Genomic context

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See Rfpl4 in Genome Data Viewer
Location:
7 A1; 7 2.96 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (5112786..5119910, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (5109787..5116911, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3697 Neighboring gene STARR-positive B cell enhancer ABC_E9020 Neighboring gene STARR-positive B cell enhancer ABC_E4891 Neighboring gene U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 Neighboring gene epsin 1 Neighboring gene STARR-positive B cell enhancer ABC_E4892 Neighboring gene RAS-like, family 2, locus 9 Neighboring gene predicted gene, 47692

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells. Rajkovic A, et al. Mech Dev, 2002 Mar. PMID 11850190
  2. RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway. Suzumori N, et al. Proc Natl Acad Sci U S A, 2003 Jan 21. PMID 12525704, Free PMC Article
  3. ELAVL2-directed RNA regulatory network drives the formation of quiescent primordial follicles. Kato Y, et al. EMBO Rep, 2019 Dec 5. PMID 31657143, Free PMC Article
  4. NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression. Rajkovic A, et al. Science, 2004 Aug 20. PMID 15326356
  5. Maternal microRNAs are essential for mouse zygotic development. Tang F, et al. Genes Dev, 2007 Mar 15. PMID 17369397, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells.
    Title: The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells.
  2. RFPL4 functions as an E3 ubiquitin protein ligase to regulate protein degradation and meiosis in mouse oocytes.
    Title: RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in female germ cell nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ret finger protein-like 4A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145013.1 → NP_001138485.1  ret finger protein-like 4A

    See identical proteins and their annotated locations for NP_001138485.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK136022, AK139569, BC069834
    Consensus CDS
    CCDS20759.1
    UniProtKB/Swiss-Prot
    Q6IS67, Q8VH31
    UniProtKB/TrEMBL
    A0A140LIN5
    Related
    ENSMUSP00000136497.2, ENSMUST00000179971.8
    Conserved Domains (3) summary
    pfam11002
    Location:54 → 95
    RDM; RFPL defining motif (RDM)
    cd15821
    Location:94 → 272
    SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4
    cl17238
    Location:11 → 52
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  2. NM_138954.3 → NP_620404.1  ret finger protein-like 4A

    See identical proteins and their annotated locations for NP_620404.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK136022, AK139569, AY070253
    Consensus CDS
    CCDS20759.1
    UniProtKB/Swiss-Prot
    Q6IS67, Q8VH31
    UniProtKB/TrEMBL
    A0A140LIN5
    Related
    ENSMUSP00000039519.8, ENSMUST00000045215.9
    Conserved Domains (3) summary
    pfam11002
    Location:54 → 95
    RDM; RFPL defining motif (RDM)
    cd15821
    Location:94 → 272
    SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4
    cl17238
    Location:11 → 52
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    5112786..5119910 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VH31.1 GenPept UniProtKB/Swiss-Prot:Q8VH31

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