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Ptprz1 protein tyrosine phosphatase receptor type Z, polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 19283, updated on 27-Nov-2024

Summary

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Official Symbol
Ptprz1provided by MGI
Official Full Name
protein tyrosine phosphatase receptor type Z, polypeptide 1provided by MGI
Primary source
MGI:MGI:97816
See related
Ensembl:ENSMUSG00000068748 AllianceGenome:MGI:97816
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ptpz; Ptprz; RPTPz; PTPbeta; PTPzeta; DSD-1-PG; Rptpbeta; R-PTP-zeta
Summary
Enables protein tyrosine phosphatase activity. Involved in several processes, including oligodendrocyte differentiation; peptidyl-tyrosine dephosphorylation; and regulation of myelination. Acts upstream of or within axonogenesis and hematopoietic progenitor cell differentiation. Located in perineuronal net and plasma membrane. Is active in synapse. Is expressed in several structures, including central nervous system; cranial nerve; eye; genitourinary system; and limb. Orthologous to human PTPRZ1 (protein tyrosine phosphatase receptor type Z1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E18 (RPKM 46.4), whole brain E14.5 (RPKM 27.1) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Ptprz1 in Genome Data Viewer
Location:
6 A3.1; 6 9.92 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (22875302..23052915)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (22875315..23052916)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene polycomb group ring finger 1 pseudogene Neighboring gene predicted gene, 18861 Neighboring gene STARR-seq mESC enhancer starr_15326 Neighboring gene STARR-seq mESC enhancer starr_15327 Neighboring gene STARR-seq mESC enhancer starr_15328 Neighboring gene STARR-seq mESC enhancer starr_15329 Neighboring gene aminoadipate-semialdehyde synthase Neighboring gene PRP18 pre-mRNA processing factor 18 homolog pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel role for receptor like protein tyrosine phosphatase zeta in modulation of sensorimotor responses to noxious stimuli: evidences from knockout mice studies. Lafont D, et al. Behav Brain Res, 2009 Jul 19. PMID 19428613
  2. Protamine neutralizes chondroitin sulfate proteoglycan-mediated inhibition of oligodendrocyte differentiation. Kuboyama K, et al. PLoS One, 2017. PMID 29216327, Free PMC Article
  3. Identification of novel splicing variants of protein tyrosine phosphatase receptor type Z. Fujikawa A, et al. J Biochem, 2017 Nov 1. PMID 28992190
  4. Inactivation of Protein Tyrosine Phosphatase Receptor Type Z by Pleiotrophin Promotes Remyelination through Activation of Differentiation of Oligodendrocyte Precursor Cells. Kuboyama K, et al. J Neurosci, 2015 Sep 2. PMID 26338327, Free PMC Article
  5. Behavioral and neurological analyses of adult mice carrying null and distinct loss-of-receptor function mutations in protein tyrosine phosphatase receptor type Z (PTPRZ). Tanga N, et al. PLoS One, 2019. PMID 31194769, Free PMC Article

See all (114) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Brain-specific glycosylation enzyme GnT-IX maintains levels of protein tyrosine phosphatase receptor PTPRZ, thereby mediating glioma growth.
    Title: Brain-specific glycosylation enzyme GnT-IX maintains levels of protein tyrosine phosphatase receptor PTPRZ, thereby mediating glioma growth.
  2. Genetic deletion or tyrosine phosphatase inhibition of PTPRZ1 activates c-Met to up-regulate angiogenesis and lung adenocarcinoma growth.
    Title: Genetic deletion or tyrosine phosphatase inhibition of PTPRZ1 activates c-Met to up-regulate angiogenesis and lung adenocarcinoma growth.
  3. Brain-specific glycosylation of protein tyrosine phosphatase receptor type Z (PTPRZ) marks a demyelination-associated astrocyte subtype.
    Title: Brain-specific glycosylation of protein tyrosine phosphatase receptor type Z (PTPRZ) marks a demyelination-associated astrocyte subtype.
  4. IL-34 and protein-tyrosine phosphatase receptor type-zeta-dependent mechanisms limit arthritis in mice.
    Title: IL-34 and protein-tyrosine phosphatase receptor type-zeta-dependent mechanisms limit arthritis in mice.
  5. Protein Tyrosine Phosphatase Receptor Type Z in Central Nervous System Disease.
    Title: Protein Tyrosine Phosphatase Receptor Type Z in Central Nervous System Disease.
  6. Protein tyrosine phosphatase receptor-zeta1 deletion triggers defective heart morphogenesis in mice and zebrafish.
    Title: Protein tyrosine phosphatase receptor-ζ1 deletion triggers defective heart morphogenesis in mice and zebrafish.
  7. The protein tyrosine phosphatase RPTPzeta/phosphacan is critical for perineuronal net structure.
    Title: The protein tyrosine phosphatase RPTPζ/phosphacan is critical for perineuronal net structure.
  8. Ptprz knock-out mice exhibited an increased locomotor response to novelty, whereas their locomotor response to methamphetamine (METH) was reduced. Furthermore, Ptprz deficiency may reduce cell surface dopamine (DA) transporter proteins expression, thereby reducing METH-evoked DA release.
    Title: Mice deficient in protein tyrosine phosphatase receptor type Z (PTPRZ) show reduced responsivity to methamphetamine despite an enhanced response to novelty.
  9. results suggest that the extracellular region of PTPRZ, including the secretory isoform, is crucial for behavioral responses to novelty and the formation of aversive memories, whereas the PTPase activities of PTPRZ receptor isoforms are involved in regulating the dopaminergic system
    Title: Behavioral and neurological analyses of adult mice carrying null and distinct loss-of-receptor function mutations in protein tyrosine phosphatase receptor type Z (PTPRZ).
  10. High PTPRZ1 expression is associated with glioblastoma.
    Title: Targeting PTPRZ inhibits stem cell-like properties and tumorigenicity in glioblastoma cells.
Submit: New GeneRIF Correction See all GeneRIFs (36)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (5)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fibroblast growth factor binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H2AXY142 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables integrin binding ISO
Inferred from Sequence Orthology
more info
  
enables integrin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein tyrosine phosphatase activity, metal-dependent IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in axonal fasciculation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within axonogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in learning or memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oligodendrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-tyrosine dephosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-tyrosine dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of Schwann cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of oligodendrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of myelination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of oligodendrocyte progenitor proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in filopodium ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in growth cone ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in perineuronal net IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perineuronal net ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
receptor-type tyrosine-protein phosphatase zeta
Names
3F8 chondroitin sulfate proteoglycan
3H1 keratan sulfate proteoglycan
phosphacan
NP_001074775.1
NP_001297993.1
NP_001348278.1
NP_001389981.1
NP_001389982.1
NP_001389983.1
NP_035349.2
XP_006505075.1
XP_006505076.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081306.2 → NP_001074775.1  receptor-type tyrosine-protein phosphatase zeta isoform 3 precursor

    See identical proteins and their annotated locations for NP_001074775.1

    Status: VALIDATED

    Source sequence(s)
    AC133599, AC134445
    Consensus CDS
    CCDS39437.1
    UniProtKB/Swiss-Prot
    B9EKR1
    Related
    ENSMUSP00000088056.4, ENSMUST00000090568.7
    Conserved Domains (4) summary
    smart00194
    Location:1713 → 1988
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:1749 → 1988
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd03122
    Location:45 → 298
    alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
    pfam00041
    Location:313 → 401
    fn3; Fibronectin type III domain

  2. NM_001311064.2 → NP_001297993.1  receptor-type tyrosine-protein phosphatase zeta isoform 4 precursor

    See identical proteins and their annotated locations for NP_001297993.1

    Status: VALIDATED

    Source sequence(s)
    AC133599, AC134445
    Consensus CDS
    CCDS80493.1
    UniProtKB/TrEMBL
    B2RXS8
    Related
    ENSMUSP00000143902.2, ENSMUST00000202102.2
    Conserved Domains (4) summary
    smart00194
    Location:864 → 1139
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:900 → 1139
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd03122
    Location:45 → 298
    alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
    pfam00041
    Location:313 → 401
    fn3; Fibronectin type III domain

  3. NM_001361349.2 → NP_001348278.1  receptor-type tyrosine-protein phosphatase zeta isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC133599, AC134445
    Conserved Domains (4) summary
    smart00194
    Location:864 → 1132
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:1191 → 1421
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd03122
    Location:45 → 298
    alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
    pfam00041
    Location:313 → 401
    fn3; Fibronectin type III domain

  4. NM_001403052.1 → NP_001389981.1  receptor-type tyrosine-protein phosphatase zeta isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC133599, AC134445

  5. NM_001403053.1 → NP_001389982.1  receptor-type tyrosine-protein phosphatase zeta isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AC133599, AC134445

  6. NM_001403054.1 → NP_001389983.1  receptor-type tyrosine-protein phosphatase zeta isoform 8 precursor

    Status: VALIDATED

    Source sequence(s)
    AC133599, AC134445

  7. NM_011219.3 → NP_035349.2  receptor-type tyrosine-protein phosphatase zeta isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC133599, AC134445
    Consensus CDS
    CCDS90032.1
    UniProtKB/TrEMBL
    A0A0J9YVD2, Q9WUT8
    Related
    ENSMUSP00000144605.2, ENSMUST00000202579.4
    Conserved Domains (2) summary
    cd03122
    Location:45 → 298
    alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
    pfam00041
    Location:313 → 401
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    22875302..23052915
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505012.3 → XP_006505075.1  receptor-type tyrosine-protein phosphatase zeta isoform X1

    Conserved Domains (4) summary
    cd03122
    Location:45 → 298
    alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
    cd17669
    Location:2080 → 2283
    R-PTP-Z-2; catalytic domain of receptor-type tyrosine-protein phosphatase Z, repeat 2
    pfam00041
    Location:313 → 395
    fn3; Fibronectin type III domain
    cl28904
    Location:1714 → 1997
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  2. XM_006505013.3 → XP_006505076.1  receptor-type tyrosine-protein phosphatase zeta isoform X2

    Conserved Domains (4) summary
    cd03122
    Location:45 → 298
    alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...
    cd17669
    Location:2073 → 2276
    R-PTP-Z-2; catalytic domain of receptor-type tyrosine-protein phosphatase Z, repeat 2
    pfam00041
    Location:313 → 395
    fn3; Fibronectin type III domain
    cl28904
    Location:1714 → 1990
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178180.1: Suppressed sequence

    Description
    NM_178180.1: This RefSeq was removed because there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B9EKR1.1 GenPept UniProtKB/Swiss-Prot:B9EKR1

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