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Rab5c RAB5C, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 19345, updated on 27-Nov-2024

Summary

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Official Symbol
Rab5cprovided by MGI
Official Full Name
RAB5C, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:105306
See related
Ensembl:ENSMUSG00000019173 AllianceGenome:MGI:105306
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rabl
Summary
Predicted to enable GDP binding activity and GTPase activity. Acts upstream of or within endosome organization and regulation of endocytosis. Located in endocytic vesicle. Is expressed in several structures, including heart; intestine; liver; lung; and spleen. Orthologous to human RAB5C (RAB5C, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in kidney adult (RPKM 167.3), duodenum adult (RPKM 128.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rab5c in Genome Data Viewer
Location:
11 D; 11 63.54 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100605829..100629041, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100715003..100738215, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene K(lysine) acetyltransferase 2A Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100575167-100575276 Neighboring gene heat shock protein, alpha-crystallin-related, B9 Neighboring gene STARR-positive B cell enhancer ABC_E3022 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 4 Neighboring gene STARR-positive B cell enhancer ABC_E8452 Neighboring gene hypocretin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structural plasticity of an invariant hydrophobic triad in the switch regions of Rab GTPases is a determinant of effector recognition. Merithew E, et al. J Biol Chem, 2001 Apr 27. PMID 11278565
  2. Rab5c promotes RSV and ADV replication by autophagy in respiratory epithelial cells. Wang X, et al. Virus Res, 2024 Mar. PMID 38242290, Free PMC Article
  3. IL-6 and IL-12 specifically regulate the expression of Rab5 and Rab7 via distinct signaling pathways. Bhattacharya M, et al. EMBO J, 2006 Jun 21. PMID 16763563, Free PMC Article
  4. Rab5 is necessary for the biogenesis of the endolysosomal system in vivo. Zeigerer A, et al. Nature, 2012 May 23. PMID 22622570
  5. Rab17, a novel small GTPase, is specific for epithelial cells and is induced during cell polarization. Lütcke A, et al. J Cell Biol, 1993 May. PMID 8486736, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GDP binding ISO
Inferred from Sequence Orthology
more info
  
enables GDP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within endosome organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in plasma membrane to endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in melanosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ras-related protein Rab-5C
NP_001291932.1
NP_077776.2
XP_036012345.1
XP_036012346.1
XP_036012347.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305003.1 → NP_001291932.1  ras-related protein Rab-5C isoform 2

    See identical proteins and their annotated locations for NP_001291932.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the penultimate exon, compared to variant 1. It encodes isoform 2 which is longer than isoform 1.
    Source sequence(s)
    AK159832, AL591469, BE447216, BY081527
    Consensus CDS
    CCDS79048.1
    UniProtKB/TrEMBL
    Q3TCT9, Q8C266
    Related
    ENSMUSP00000019317.6, ENSMUST00000019317.12
    Conserved Domains (2) summary
    cd01860
    Location:21 → 201
    Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
    pfam00071
    Location:23 → 202
    Ras; Ras family

  2. NM_024456.5 → NP_077776.2  ras-related protein Rab-5C isoform 1

    See identical proteins and their annotated locations for NP_077776.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AK159832, AL591469, BE447216, BY081527
    Consensus CDS
    CCDS36333.1
    UniProtKB/Swiss-Prot
    P35278, Q8R1V8, Q8R2N8
    UniProtKB/TrEMBL
    Q3TCT9, Q3TJ39
    Related
    ENSMUSP00000102987.2, ENSMUST00000107364.8
    Conserved Domains (1) summary
    cd01860
    Location:21 → 183
    Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100605829..100629041 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156453.1 → XP_036012346.1  ras-related protein Rab-5C isoform X2

    UniProtKB/TrEMBL
    Q3TCT9
    Conserved Domains (1) summary
    cd01860
    Location:67 → 229
    Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

  2. XM_036156452.1 → XP_036012345.1  ras-related protein Rab-5C isoform X1

    Conserved Domains (1) summary
    cd01860
    Location:67 → 247
    Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

  3. XM_036156454.1 → XP_036012347.1  ras-related protein Rab-5C isoform X3

    UniProtKB/Swiss-Prot
    P35278, Q8R1V8, Q8R2N8
    UniProtKB/TrEMBL
    Q3TCT9, Q3TJ39
    Conserved Domains (1) summary
    cd01860
    Location:21 → 183
    Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35278.2 GenPept UniProtKB/Swiss-Prot:P35278

Gene LinkOut

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