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Vps37d vacuolar protein sorting 37D [ Mus musculus (house mouse) ]

Gene ID: 194309, updated on 27-Nov-2024

Summary

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Official Symbol
Vps37dprovided by MGI
Official Full Name
vacuolar protein sorting 37Dprovided by MGI
Primary source
MGI:MGI:2159402
See related
Ensembl:ENSMUSG00000043614 AllianceGenome:MGI:2159402
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wbscr24
Summary
Predicted to be involved in protein targeting to membrane; protein targeting to vacuole; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be located in late endosome membrane. Predicted to be part of ESCRT I complex. Is expressed in brain; cartilage; spinal cord; testis; and trachea. Orthologous to human VPS37D (VPS37D subunit of ESCRT-I). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in whole brain E14.5 (RPKM 17.3), CNS E18 (RPKM 15.8) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Vps37d in Genome Data Viewer
Location:
5 G2; 5 74.98 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (135101751..135107197, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (135072899..135078326, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25492 Neighboring gene BUD23, rRNA methyltransferase and ribosome maturation factor Neighboring gene STARR-positive B cell enhancer ABC_E673 Neighboring gene DnaJ heat shock protein family (Hsp40) member C30 Neighboring gene STARR-seq mESC enhancer starr_14566 Neighboring gene MLX interacting protein-like Neighboring gene STARR-positive B cell enhancer ABC_E855 Neighboring gene STARR-positive B cell enhancer ABC_E280 Neighboring gene transducin (beta)-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC51411

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of ESCRT I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESCRT I complex ISO
Inferred from Sequence Orthology
more info
  
part_of ESCRT I complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
vacuolar protein sorting-associated protein 37D
Names
ESCRT-I complex subunit VPS37D
Williams-Beuren syndrome chromosome region 24 homolog
Williams-Beuren syndrome critical region protein 24
williams-Beuren syndrome region protein 24 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199677.2 → NP_001186606.1  vacuolar protein sorting-associated protein 37D isoform 1

    See identical proteins and their annotated locations for NP_001186606.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AC084109
    Consensus CDS
    CCDS57388.1
    UniProtKB/Swiss-Prot
    Q80UX4, Q810I0, Q8C1V8
    Related
    ENSMUSP00000063762.5, ENSMUST00000067935.11
    Conserved Domains (2) summary
    PTZ00449
    Location:198 → 259
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam07200
    Location:22 → 165
    Mod_r; Modifier of rudimentary (Mod(r)) protein

  2. NM_177574.5 → NP_808242.1  vacuolar protein sorting-associated protein 37D isoform 2

    See identical proteins and their annotated locations for NP_808242.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AC084109
    Consensus CDS
    CCDS19733.1
    UniProtKB/Swiss-Prot
    Q810I0
    Related
    ENSMUSP00000075559.3, ENSMUST00000076203.3
    Conserved Domains (1) summary
    pfam07200
    Location:22 → 92
    Mod_r; Modifier of rudimentary (Mod(r)) protein

RNA

  1. NR_189596.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC084109

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    135101751..135107197 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240872.4 → XP_011239174.1  vacuolar protein sorting-associated protein 37D isoform X1

    Conserved Domains (2) summary
    PTZ00449
    Location:191 → 252
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam07200
    Location:39 → 158
    Mod_r; Modifier of rudimentary (Mod(r)) protein

RNA

  1. XR_001784645.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q810I0.2 GenPept UniProtKB/Swiss-Prot:Q810I0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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