Reg2 regenerating islet-derived 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Reg2provided by MGI
Official Full Name: regenerating islet-derived 2provided by MGI
Primary source: MGI:MGI:97896
See related: Ensembl:ENSMUSG00000023140 AllianceGenome:MGI:97896
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PSP; PTP; REG-2
Summary: Predicted to enable several functions, including molecular function inhibitor activity; oligosaccharide binding activity; and peptidoglycan binding activity. Acts upstream of or within myelination and suckling behavior. Located in collagen-containing extracellular matrix. Is expressed in several structures, including gut; male reproductive gland or organ; and mesenteric adipose tissue. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to several human genes including REG1A (regenerating family member 1 alpha). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Restricted expression toward small intestine adult (RPKM 155.3) See more
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Genomic context

Location:: 6 C3; 6 34.77 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (78382138..78385082)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (78405155..78408099)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role and mechanism of REG2 depletion in insulin secretion augmented by glutathione peroxidase-1 overproduction.
Title: Role and mechanism of REG2 depletion in insulin secretion augmented by glutathione peroxidase-1 overproduction.
Normal expression of Reg2 gene is required for appropriate compensations in pancreatic islet proliferation and expansion in response to obesity and aging.
Title: Reg2 Expression Is Required for Pancreatic Islet Compensation in Response to Aging and High-Fat Diet-Induced Obesity.
mReg2 inhibits AIF-mediated apoptosis by promoting the nuclear presence of Scythe and inducing hsp70.
Title: mReg2 inhibits nuclear entry of apoptosis-inducing factor in mouse insulinoma cells.
Reg2 induces glucose-regulated peptide 78 (GRP78) expression via the Akt-mTORC1 axis.
Title: Attenuation of unfolded protein response and apoptosis by mReg2 induced GRP78 in mouse insulinoma cells.
Direct stimulation of Reg2 and Reg3beta genes by glucocorticoids.
Title: Transcriptional activation of Reg2 and Reg3β genes by glucocorticoids and interleukin-6 in pancreatic acinar and islet cells.
Reg2, Reg3alpha, and Reg3beta were abundantly expressed in most acinar cells of the pancreas with clear age-dependent and isoform-specific patterns.
Title: Coordinated age-dependent and pancreatic-specific expression of mouse Reg2Reg3α, and Reg3β genes.
Reg2 protects MIN6 cells from streptozotocin-induced apoptosis by attenuating streptozotocin's ability to disrupt mitochondrial membrane integrity, activate caspase-3 and promote poly-ADP ribose polymerase cleavage, and induce apoptosis.
Title: Reg2 protects mouse insulinoma cells from streptozotocin-induced mitochondrial disruption and apoptosis.
adjuvant immunotherapy regulates type 1 diabetes in diabetic mice and induces Reg2-mediated regeneration of beta cells
Title: Adjuvant immunotherapy increases beta cell regenerative factor Reg2 in the pancreas of diabetic mice.
Overexpression of Reg2 gene offered no protection against streptozotocin-induced beta-cell damage and diabetes and did not protect acinar cells against caerulein-induced acute pancreatitis.
Title: Pancreatic acinar-specific overexpression of Reg2 gene offered no protection against either experimental diabetes or pancreatitis in mice.
RegII is a novel beta-cell-derived autoantigen in NOD mice. The autoimmune response against this protein may convert a regenerative into an islet-destructive process accelerating development of type 1 diabetes. [regII protein]
Title: RegII is a beta-cell protein and autoantigen in diabetes of NOD mice.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

General gene information

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Markers

Reg1 (e-PCR), detects polymorphism
- UniSTS:259509

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info
enables oligosaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptidoglycan binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to peptide hormone	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within suckling behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: lithostathine-2

Names: islet of Langerhans regenerating protein 2; pancreatic stone protein 2; pancreatic thread protein 2; regenerating islet-derived, mouse homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.