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Ren2 renin 2 tandem duplication of Ren1 [ Mus musculus (house mouse) ]

Gene ID: 19702, updated on 4-Jan-2025

Summary

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Official Symbol
Ren2provided by MGI
Official Full Name
renin 2 tandem duplication of Ren1provided by MGI
Primary source
MGI:MGI:97899
See related
AllianceGenome:MGI:97899
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ren; Rnr; Rn-2; Ren-2; Ren-B
Summary
Enables endopeptidase activity. Acts upstream of or within with a negative effect on gene expression. Acts upstream of or within positive regulation of blood pressure. Located in extracellular space. Is expressed in several structures, including adrenal medulla; embryo mesenchyme; medulla oblongata alar plate mantle layer; metanephros; and submandibular gland. Human ortholog(s) of this gene implicated in essential hypertension; familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information
not in current annotation release
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Genomic context

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See Ren2 in Genome Data Viewer
Location:
1 E4; 1
Annotation release Status Assembly Chr Location
108.20200622 latest, but not current GRCm38.p6 (GCF_000001635.26) 1 Unlocalized Scaffold (129S6/SvEvTac) NT_039192.2 (159748..169505, complement)

Bibliography

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Related articles in PubMed

  1. Roles of nitric oxide and oxidative stress in the regulation of blood pressure and renal function in prehypertensive Ren-2 transgenic rats. Vanecková I, et al. Kidney Blood Press Res, 2005. PMID 15795515
  2. Amino acid sequence of mouse submaxillary gland renin. Misono KS, et al. Proc Natl Acad Sci U S A, 1982 Aug. PMID 6812055, Free PMC Article
  3. Complete amino acid sequence and maturation of the mouse submaxillary gland renin precursor. Panthier JJ, et al. Nature, 1982 Jul 1. PMID 6283373
  4. Angiotensin II-induced non-alcoholic fatty liver disease is mediated by oxidative stress in transgenic TG(mRen2)27(Ren2) rats. Wei Y, et al. J Hepatol, 2008 Sep. PMID 18486983, Free PMC Article
  5. Ovariectomy is protective against renal injury in the high-salt-fed older mRen2. Lewis rat. Yamaleyeva LM, et al. Am J Physiol Heart Circ Physiol, 2007 Oct. PMID 17630347

See all (106) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Increased Susceptibility of Mice Lacking Renin-b to Angiotensin II-Induced Organ Damage.
    Title: Increased Susceptibility of Mice Lacking Renin-b to Angiotensin II-Induced Organ Damage.
  2. Sex differences in blood pressure of aged Ren-2 transgenic rats.
    Title: Sex differences in blood pressure of aged Ren-2 transgenic rats.
  3. Intrapulmonary activation of the angiotensin-converting enzyme type 2/angiotensin 1-7/G-protein-coupled Mas receptor axis attenuates pulmonary hypertension in Ren-2 transgenic rats exposed to chronic hypoxia.
    Title: Intrapulmonary activation of the angiotensin-converting enzyme type 2/angiotensin 1-7/G-protein-coupled Mas receptor axis attenuates pulmonary hypertension in Ren-2 transgenic rats exposed to chronic hypoxia.
  4. Suppression of ACE-ANG II axis in the circulation and kidney tissue, combined with augmentation of the intrarenal vasodilator ACE2-ANG 1-7 axis, is the main mechanism responsible for blood pressure-lowering effects of chronic hypoxia in mRen2 rat.
    Title: Combined suppression of the intrarenal and circulating vasoconstrictor renin-ACE-ANG II axis and augmentation of the vasodilator ACE2-ANG 1-7-Mas axis attenuates the systemic hypertension in Ren-2 transgenic rats exposed to chronic hypoxia.
  5. BP-lowering effect of sEH inhibition in I3C-induced Cyp1a1-Ren-2 transgenic rats.
    Title: Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: studies in Cyp1a1-Ren-2 transgenic rats.
  6. Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats.
    Title: Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats.
  7. A deficitcin Ang-(1-7) in the brain of hypertensive (mRen2)27 rats maycbe a contributing factor to higher blood pressure and alteredcautonomic balance in this strain.
    Title: In vivo expression of angiotensin-(1-7) lowers blood pressure and improves baroreflex function in transgenic (mRen2)27 rats.
  8. Data show that the GPR30 agonist G-1 mitigates the adverse effects of oestrogen loss on LV remodelling and the development of diastolic dysfunction in oophorectomized mRen2 Lew rats.
    Title: Activation of GPR30 attenuates diastolic dysfunction and left ventricle remodelling in oophorectomized mRen2.Lewis rats.
  9. Renin and PPAR-gamma differentially contribute to the control of the length of cardiomyocytes.
    Title: Controlling cardiomyocyte length: the role of renin and PPAR-{gamma}.
  10. Epoxide hydrolase inhibitors displays antihypertensive effects in Ren-2 transgenic rats with inducible malignant hypertension via an improvement of renal function.
    Title: Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats with inducible hypertension.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables aspartic-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables insulin-like growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in angiotensin maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in angiotensin maturation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within_negative_effect gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in kidney development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of blood pressure IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
  
involved_in response to cAMP ISO
Inferred from Sequence Orthology
more info
  
involved_in response to cGMP ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
renin-2
Names
angiotensinogenase
submandibular gland renin
NP_112470.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031193.2 → NP_112470.2  renin-2 precursor

    Status: VALIDATED

    Source sequence(s)
    BC011157, BG867251, BG869802
    UniProtKB/Swiss-Prot
    P00796, P70229, P97955, Q62155
    Conserved Domains (3) summary
    cd05487
    Location:98 → 423
    renin_like; Renin stimulates production of angiotensin and thus affects blood pressure
    pfam00026
    Location:105 → 423
    Asp; Eukaryotic aspartyl protease
    pfam07966
    Location:51 → 76
    A1_Propeptide; A1 Propeptide
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00796.1 GenPept UniProtKB/Swiss-Prot:P00796

Gene LinkOut

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