U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

KRTCAP2 keratinocyte associated protein 2 [ Homo sapiens (human) ]

Gene ID: 200185, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
KRTCAP2provided by HGNC
Official Full Name
keratinocyte associated protein 2provided by HGNC
Primary source
HGNC:HGNC:28942
See related
Ensembl:ENSG00000163463 MIM:619029; AllianceGenome:HGNC:28942
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KCP2
Summary
Enables enzyme activator activity. Involved in protein N-linked glycosylation. Part of oligosaccharyltransferase complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 48.6), fat (RPKM 46.3) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See KRTCAP2 in Genome Data Viewer
Location:
1q22
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (155169408..155173304, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (154309025..154312920, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155141884..155145780, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1807 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1808 Neighboring gene dolichyl-phosphate mannosyltransferase subunit 3, regulatory Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 18 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1395 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1809 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:155145543-155146051 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:155146052-155146560 Neighboring gene Sharpr-MPRA regulatory region 7923 Neighboring gene tripartite motif containing 46 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:155157269-155157776 Neighboring gene mucin 1, cell surface associated

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. KRTCAP2 as an immunological and prognostic biomarker of hepatocellular carcinoma. Sun P, et al. Colloids Surf B Biointerfaces, 2023 Feb. PMID 36634487
  2. DC2 and KCP2 mediate the interaction between the oligosaccharyltransferase and the ER translocon. Shrimal S, et al. J Cell Biol, 2017 Nov 6. PMID 28860277, Free PMC Article
  3. Keratinocyte-associated protein 2 is a bona fide subunit of the mammalian oligosaccharyltransferase. Roboti P, et al. J Cell Sci, 2012 Jan 1. PMID 22266900
  4. Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes. Bonkobara M, et al. Br J Dermatol, 2003 Apr. PMID 12752121
  5. The oligosaccharyltransferase subunits OST48, DAD1 and KCP2 function as ubiquitous and selective modulators of mammalian N-glycosylation. Roboti P, et al. J Cell Sci, 2012 Jul 15. PMID 22467853

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KRTCAP2 as an immunological and prognostic biomarker of hepatocellular carcinoma.
    Title: KRTCAP2 as an immunological and prognostic biomarker of hepatocellular carcinoma.
  2. DC2 and KCP2 mediate the interaction between the oligosaccharyltransferase STT3A and the endoplasmic reticulum translocon.
    Title: DC2 and KCP2 mediate the interaction between the oligosaccharyltransferase and the ER translocon.
  3. data strongly support the proposal that KCP2 is a newly identified subunit of the N-glycosylation machinery present in a subset of eukaryotes
    Title: Keratinocyte-associated protein 2 is a bona fide subunit of the mammalian oligosaccharyltransferase.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of oligosaccharyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
keratinocyte-associated protein 2
Names
KCP-2
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2
keratinocytes associated protein 2
oligosaccharyl transferase subunit KCP2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173852.4 → NP_776251.2  keratinocyte-associated protein 2

    Status: VALIDATED

    Source sequence(s)
    AL607067
    Consensus CDS
    CCDS1096.2
    UniProtKB/Swiss-Prot
    B2R4Q1, Q6PG45, Q86XW2, Q8IWS4, Q8N6L1
    Related
    ENSP00000295682.5, ENST00000295682.6
    Conserved Domains (1) summary
    pfam09775
    Location:3 → 131
    Keratin_assoc; Keratinocyte-associated protein 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    155169408..155173304 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    154309025..154312920 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N6L1.2 GenPept UniProtKB/Swiss-Prot:Q8N6L1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools