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ELK3 ETS transcription factor ELK3 [ Homo sapiens (human) ]

Gene ID: 2004, updated on 27-Nov-2024

Summary

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Official Symbol
ELK3provided by HGNC
Official Full Name
ETS transcription factor ELK3provided by HGNC
Primary source
HGNC:HGNC:3325
See related
Ensembl:ENSG00000111145 MIM:600247; AllianceGenome:HGNC:3325
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERP; NET; SAP2; SAP-2
Summary
This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Annotation information
Note: NET is an alias on both SLC6A2 (Gene ID: 6530, "norepinephrine transporter") and ELK3 (Gene ID: 2004). [01 Jun 2018]
Expression
Ubiquitous expression in spleen (RPKM 23.7), endometrium (RPKM 22.8) and 24 other tissues See more
Orthologs
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Genomic context

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See ELK3 in Genome Data Viewer
Location:
12q23.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (96194375..96269824)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (96168506..96244027)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (96588153..96663602)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369923 Neighboring gene RNA, 7SL, cytoplasmic 88, pseudogene Neighboring gene Sharpr-MPRA regulatory region 6189 Neighboring gene long intergenic non-protein coding RNA 2452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4741 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6825 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:96603880-96604402 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6826 Neighboring gene uncharacterized LOC124902991 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:96628784-96629768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:96631810-96632310 Neighboring gene cyclin dependent kinase 17 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:96709352-96709984 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:96709985-96710615 Neighboring gene RNA, U4 small nuclear 24, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4743 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4744 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6827 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4745 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6828 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6830 Neighboring gene RN7SK pseudogene 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ETS transcription factor ELK3 in human cancers: An emerging therapeutic target. Al-Hawary SIS, et al. Pathol Res Pract, 2023 Aug. PMID 37542863
  2. ELK3 expressed in lymphatic endothelial cells promotes breast cancer progression and metastasis through exosomal miRNAs. Kim KS, et al. Sci Rep, 2019 Jun 10. PMID 31182803, Free PMC Article
  3. The net repressor is regulated by nuclear export in response to anisomycin, UV, and heat shock. Ducret C, et al. Mol Cell Biol, 1999 Oct. PMID 10490644, Free PMC Article
  4. Growth inhibitory effect of the ternary complex factor Net on human pancreatic carcinoma cell lines. Li B, et al. Tohoku J Exp Med, 2008 Oct. PMID 18832796
  5. Molecular and clinical features of a potential immunotherapy target ELK3 in glioma. Xu H, et al. Medicine (Baltimore), 2022 Jul 29. PMID 35905257, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ELK3 destabilization by speckle-type POZ protein suppresses prostate cancer progression and docetaxel resistance.
    Title: ELK3 destabilization by speckle-type POZ protein suppresses prostate cancer progression and docetaxel resistance.
  2. ELK3-ID4 axis governs the metastatic features of triple negative breast cancer.
    Title: ELK3-ID4 axis governs the metastatic features of triple negative breast cancer.
  3. ETS transcription factor ELK3 in human cancers: An emerging therapeutic target.
    Title: ETS transcription factor ELK3 in human cancers: An emerging therapeutic target.
  4. ELK3 Targeting AEG1 Promotes Migration and Invasion of Ovarian Cancer Cells under Hypoxia.
    Title: ELK3 Targeting AEG1 Promotes Migration and Invasion of Ovarian Cancer Cells under Hypoxia.
  5. ELK3-CXCL16 axis determines natural killer cell cytotoxicity via the chemotactic activity of CXCL16 in triple negative breast cancer.
    Title: ELK3-CXCL16 axis determines natural killer cell cytotoxicity via the chemotactic activity of CXCL16 in triple negative breast cancer.
  6. Deubiquitinase UCHL5 stabilizes ELK3 to potentiate cancer stemness and tumor progression in pancreatic adenocarcinoma (PAAD).
    Title: Deubiquitinase UCHL5 stabilizes ELK3 to potentiate cancer stemness and tumor progression in pancreatic adenocarcinoma (PAAD).
  7. Circular RNA hsa_circ_0000144 aggravates ovarian Cancer progression by regulating ELK3 via sponging miR-610.
    Title: Circular RNA hsa_circ_0000144 aggravates ovarian Cancer progression by regulating ELK3 via sponging miR-610.
  8. Molecular and clinical features of a potential immunotherapy target ELK3 in glioma.
    Title: Molecular and clinical features of a potential immunotherapy target ELK3 in glioma.
  9. ELK3 Controls Gastric Cancer Cell Migration and Invasion by Regulating ECM Remodeling-Related Genes.
    Title: ELK3 Controls Gastric Cancer Cell Migration and Invasion by Regulating ECM Remodeling-Related Genes.
  10. [Expression characteristics and functional analysis of ELK3 in gastric cancer].
    Title: [Expression characteristics and functional analysis of ELK3 in gastric cancer].
Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies ALLC polymorphisms correlated with FEV₁ change by corticosteroid.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables purine-rich negative regulatory element binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in wound healing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ETS domain-containing protein Elk-3
Names
ELK3, ETS transcription factor
ELK3, ETS-domain protein (SRF accessory protein 2)
ETS-related protein ERP
ETS-related protein NET
SRF accessory protein 2
serum response factor accessory protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303511.2 → NP_001290440.1  ETS domain-containing protein Elk-3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks several exon in the 5' UTR and coding region and uses an alternate 5' most exon compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC008149, AL705041, AW575797

  2. NM_001413760.1 → NP_001400689.1  ETS domain-containing protein Elk-3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC008149
    UniProtKB/Swiss-Prot
    B2R6S6, P41970, Q6FG57, Q6GU29, Q9UD17

  3. NM_001413761.1 → NP_001400690.1  ETS domain-containing protein Elk-3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC008149
    UniProtKB/Swiss-Prot
    B2R6S6, P41970, Q6FG57, Q6GU29, Q9UD17

  4. NM_001413762.1 → NP_001400691.1  ETS domain-containing protein Elk-3 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC008149

  5. NM_001413763.1 → NP_001400692.1  ETS domain-containing protein Elk-3 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC008149

  6. NM_001413764.1 → NP_001400693.1  ETS domain-containing protein Elk-3 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC008149

  7. NM_001413765.1 → NP_001400694.1  ETS domain-containing protein Elk-3 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC008149

  8. NM_005230.4 → NP_005221.2  ETS domain-containing protein Elk-3 isoform 1

    See identical proteins and their annotated locations for NP_005221.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 3, and 4 all encode the same isoform (1).
    Source sequence(s)
    AC008149, AK312694, AW575797, DA754301
    Consensus CDS
    CCDS9060.1
    UniProtKB/Swiss-Prot
    B2R6S6, P41970, Q6FG57, Q6GU29, Q9UD17
    Related
    ENSP00000228741.3, ENST00000228741.8
    Conserved Domains (1) summary
    smart00413
    Location:19 → 88
    ETS; erythroblast transformation specific domain

RNA

  1. NR_182212.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC008149

  2. NR_182213.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC008149

  3. NR_182214.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC008149

  4. NR_182215.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC008149

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    96194375..96269824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    96168506..96244027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41970.2 GenPept UniProtKB/Swiss-Prot:P41970

Gene LinkOut

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Chemical Information
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