Nkx1-2 NK1 homeobox 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nkx1-2provided by MGI
Official Full Name: NK1 homeobox 2provided by MGI
Primary source: MGI:MGI:104806
See related: Ensembl:ENSMUSG00000048528 AllianceGenome:MGI:104806
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sax1; Nkx-1.1; Nkx-1.2
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; hemolymphoid system; male reproductive system; and primitive streak. Orthologous to human NKX1-2 (NK1 homeobox 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E11.5 (RPKM 1.3), duodenum adult (RPKM 0.3) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 76.3 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (132197968..132201366, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (132596239..132599637, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Wnt-dependent master regulator NKX1-2 controls mouse pre-implantation development.
Title: The Wnt-dependent master regulator NKX1-2 controls mouse pre-implantation development.
Results suggest a role for NK1 homeobox 2 (NKX1-2) in promoting adipogenesis and possibly in regulating the balance between adipocyte and osteoblast differentiation of bone marrow mesenchymal precursor cells.
Title: The transcription factor NKX1-2 promotes adipogenesis and may contribute to a balance between adipocyte and osteoblast differentiation.
This study identifies Nkx1-2-expressing cells as the source of most trunk and tail tissues in the mouse.
Title: Lineage tracing of axial progenitors using Nkx1-2CreER(T2) mice defines their trunk and tail contributions.
In this study use a combination of genomics, CRISPR/Cas9 engineering and TF motif analysis to investigate the transcriptional networks guiding development of the MGE and its descendants. Whereas NKX2-1 is required for initiating MGE characteristics in the VZ.
Title: Genomic analysis of transcriptional networks directing progression of cell states during MGE development.
These results suggest that Nkx1-2 is a critical component of the gene regulatory network that operates downstream of Wnt/b-catenin signaling to regulate the formation of mesendoderm.
Title: Nkx1-2 is a transcriptional repressor and is essential for the activation of Brachyury in P19 mouse embryonal carcinoma cell.
In neurokinin 1 receptor knockout retinas no changes were seen: neurokinin 3 receptor mRNA levels as well as substance P and neurokinin 3 receptor immunostainings were similar to wild types.
Title: Expression of substance P, neurokinin 1 receptors (NK1) and neurokinin 3 receptors in the developing mouse retina and in the retina of NK1 knockout mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235794

NoName (e-PCR)
- UniSTS:235795

X75384 (e-PCR)
- UniSTS:125844

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NK1 transcription factor-related protein 2

Names: NK1 transcription factor related, locus 2; homeobox protein Nkx1.2E427; homeobox protein SAX-1; spinal cord axial homeobox gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.