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Scin scinderin [ Mus musculus (house mouse) ]

Gene ID: 20259, updated on 27-Nov-2024

Summary

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Official Symbol
Scinprovided by MGI
Official Full Name
scinderinprovided by MGI
Primary source
MGI:MGI:1306794
See related
Ensembl:ENSMUSG00000002565 AllianceGenome:MGI:1306794
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
adseverin
Summary
Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including actin polymerization or depolymerization; positive regulation of megakaryocyte differentiation; and regulation of actin filament organization. Located in brush border. Is expressed in several structures, including adrenal gland; female reproductive system; gut; hemolymphoid system gland; and metanephros. Orthologous to human SCIN (scinderin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in colon adult (RPKM 56.3), large intestine adult (RPKM 22.6) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Scin in Genome Data Viewer
Location:
12 B1; 12 18.06 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (40109768..40184227, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (40059769..40134228, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr12:40763838-40764139 Neighboring gene STARR-positive B cell enhancer ABC_E7130 Neighboring gene ADP-ribosylation factor-like 4A, opposite strand Neighboring gene ADP-ribosylation factor-like 4A Neighboring gene leucine-rich single-pass membrane protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:40926695-40926804 Neighboring gene interferon-related developmental regulator 1 Neighboring gene microRNA 1938

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Murine adseverin (D5), a novel member of the gelsolin family, and murine adseverin are induced by interleukin-9 in T-helper lymphocytes. Robbens J, et al. Mol Cell Biol, 1998 Aug. PMID 9671468, Free PMC Article
  2. Adseverin, an actin-binding protein, modulates hypertrophic chondrocyte differentiation and osteoarthritis progression. Chan B, et al. Sci Adv, 2023 Aug 4. PMID 37540756, Free PMC Article
  3. The actin binding protein adseverin regulates osteoclastogenesis. Hassanpour S, et al. PLoS One, 2014. PMID 25275604, Free PMC Article
  4. Adseverin plays a role in osteoclast differentiation and periodontal disease-mediated bone loss. Jiang H, et al. FASEB J, 2015 Jun. PMID 25681458
  5. Deletion of Adseverin in Osteoclasts Affects Cell Structure But Not Bone Metabolism. Cao Y, et al. Calcif Tissue Int, 2017 Aug. PMID 28389691, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Scinderin Promotes Hydrogen Peroxide-induced Lens Epithelial Cell Injury in Age-related Cataract.
    Title: Scinderin Promotes Hydrogen Peroxide-induced Lens Epithelial Cell Injury in Age-related Cataract.
  2. Autophagy regulation and protein kinase activity of PIK3C3 controls sertoli cell polarity through its negative regulation on SCIN (scinderin).
    Title: Autophagy regulation and protein kinase activity of PIK3C3 controls sertoli cell polarity through its negative regulation on SCIN (scinderin).
  3. Adseverin, an actin-binding protein, modulates hypertrophic chondrocyte differentiation and osteoarthritis progression.
    Title: Adseverin, an actin-binding protein, modulates hypertrophic chondrocyte differentiation and osteoarthritis progression.
  4. Scinderin promotes fusion of electron transport chain dysfunctional muscle stem cells with myofibers.
    Title: Scinderin promotes fusion of electron transport chain dysfunctional muscle stem cells with myofibers.
  5. IL1beta and TNFalpha enhance RANKL-dependent expression of adseverin, which contributes to fusion processes in osteoclastogenesis
    Title: IL1β and TNFα promote RANKL-dependent adseverin expression and osteoclastogenesis.
  6. indicate that in healthy, developing tissues, adseverin contributes to the regulation of osteoclast structure but not to bone metabolism in vivo
    Title: Deletion of Adseverin in Osteoclasts Affects Cell Structure But Not Bone Metabolism.
  7. Adseverin knockdown also suppressed the RANKL-mediated induction of nuclear factor of activated T-cell c1 (NFATc1), which is a key transcription factor in osteoclastogenesis.
    Title: Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1.
  8. Data indicate that adseverin (Ads) regulates actin cytoskeleton in osteoclasts.
    Title: Adseverin plays a role in osteoclast differentiation and periodontal disease-mediated bone loss.
  9. Ads is a RANKL induced early regulator of osteoclastogenesis with a potential role in pre-osteoclast differentiation and fusion.
    Title: The actin binding protein adseverin regulates osteoclastogenesis.
  10. Overexpression of Scin is associated with asthma.
    Title: New asthma biomarkers: lessons from murine models of acute and chronic asthma.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament capping IEA
Inferred from Electronic Annotation
more info
  
involved_in actin filament capping ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament severing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament severing IEA
Inferred from Electronic Annotation
more info
  
involved_in actin filament severing ISO
Inferred from Sequence Orthology
more info
  
involved_in actin polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of actin nucleation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of actin nucleation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of megakaryocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of megakaryocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chondrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sequestering of actin monomers IEA
Inferred from Electronic Annotation
more info
  
involved_in sequestering of actin monomers ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in brush border IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in podosome IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
scinderin
Names
gelsolin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146196.1 → NP_001139668.1  scinderin isoform 1

    See identical proteins and their annotated locations for NP_001139668.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC063328, BY201136, Y13971
    Consensus CDS
    CCDS49055.1
    UniProtKB/Swiss-Prot
    O08988, O08990, Q60604, Q6P4N8
    UniProtKB/TrEMBL
    Q69Z71
    Related
    ENSMUSP00000002640.6, ENSMUST00000002640.6
    Conserved Domains (6) summary
    cd11288
    Location:508 → 598
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:136 → 225
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:10 → 121
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:613 → 711
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:246 → 346
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:390 → 486
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

  2. NM_009132.2 → NP_033158.2  scinderin isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two exons in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AK136080, BY201136, Y13971
    Consensus CDS
    CCDS25891.1
    UniProtKB/TrEMBL
    Q69Z71
    Related
    ENSMUSP00000077573.8, ENSMUST00000078481.14
    Conserved Domains (5) summary
    cd11289
    Location:136 → 225
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:10 → 121
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:509 → 611
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:246 → 346
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:390 → 486
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    40109768..40184227 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60604.3 GenPept UniProtKB/Swiss-Prot:Q60604

Gene LinkOut

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