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Sema7a sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A [ Mus musculus (house mouse) ]

Gene ID: 20361, updated on 27-Nov-2024

Summary

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Official Symbol
Sema7aprovided by MGI
Official Full Name
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7Aprovided by MGI
Primary source
MGI:MGI:1306826
See related
Ensembl:ENSMUSG00000038264 AllianceGenome:MGI:1306826
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Semal; CDw108; sema L; sema K1; H-Sema-L; M-Sema-L; H-Sema K1; 2900057C09Rik
Summary
Enables integrin binding activity. Involved in several processes, including integrin-mediated signaling pathway; positive regulation of ERK1 and ERK2 cascade; and positive regulation of macrophage cytokine production. Acts upstream of or within nervous system development; positive regulation of axon extension; and positive regulation of protein phosphorylation. Located in external side of plasma membrane. Is active in GABA-ergic synapse and presynapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in progressive familial intrahepatic cholestasis. Orthologous to human SEMA7A (semaphorin 7A (JohnMiltonHagen blood group)). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in ovary adult (RPKM 69.7), cerebellum adult (RPKM 47.2) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Sema7a in Genome Data Viewer
Location:
9 B; 9 31.63 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (57846879..57870148)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (57939596..57962865)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24249 Neighboring gene meiotic nuclear divisions 1 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_24251 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57758633-57758820 Neighboring gene ubiquitin-like 7 (bone marrow stromal cell-derived) Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57804760-57804959 Neighboring gene STARR-positive B cell enhancer ABC_E8291 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57816329-57816438 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57819923-57820197 Neighboring gene STARR-seq mESC enhancer starr_24252 Neighboring gene STARR-positive B cell enhancer ABC_E2890 Neighboring gene STARR-seq mESC enhancer starr_24253 Neighboring gene Cyp11a1 promoter region Neighboring gene cytochrome P450, family 11, subfamily a, polypeptide 1 Neighboring gene ADP-ribosylation factor-like 6 interacting protein 1 pseudogene Neighboring gene coiled-coil domain containing 33 Neighboring gene predicted gene 16130

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Semaphorin 7A as a Potential Therapeutic Target for Multiple Sclerosis. Gutiérrez-Franco A, et al. Mol Neurobiol, 2017 Aug. PMID 27714632
  2. Semaphorin 7A plays a critical role in IgE-mediated airway inflammation in mice. Mizutani N, et al. Eur J Pharmacol, 2015 Oct 5. PMID 26144372
  3. Semaphorin 7a links nerve regeneration and inflammation in the cornea. Namavari A, et al. Invest Ophthalmol Vis Sci, 2012 Jul 9. PMID 22700709, Free PMC Article
  4. Semaphorin 7A promotes angiogenesis in an experimental corneal neovascularization model. Ghanem RC, et al. Curr Eye Res, 2011 Nov. PMID 21999225, Free PMC Article
  5. Role of semaphorin 7a signaling in transforming growth factor β1-induced lung fibrosis and scleroderma-related interstitial lung disease. Gan Y, et al. Arthritis Rheum, 2011 Aug. PMID 21484765, Free PMC Article

See all (91) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Semaphorin 7a regulates inflammatory mediators and permeability in retinal endothelial cells.
    Title: Semaphorin 7a regulates inflammatory mediators and permeability in retinal endothelial cells.
  2. Sema7A protects against high-fat diet-induced obesity and hepatic steatosis by regulating adipo/lipogenesis.
    Title: Sema7A protects against high-fat diet-induced obesity and hepatic steatosis by regulating adipo/lipogenesis.
  3. Semaphorin 7A interacts with nuclear factor NF-kappa-B p105 via integrin beta1 and mediates inflammation.
    Title: Semaphorin 7A interacts with nuclear factor NF-kappa-B p105 via integrin β1 and mediates inflammation.
  4. Knockdown of SEMA7A alleviates MPP[+] -induced apoptosis and inflammation in BV2 microglia via PPAR-gamma activation and MAPK inactivation.
    Title: Knockdown of SEMA7A alleviates MPP(+) -induced apoptosis and inflammation in BV2 microglia via PPAR-γ activation and MAPK inactivation.
  5. SEMA7AR148W mutation promotes lipid accumulation and NAFLD progression via increased localization on the hepatocyte surface.
    Title: SEMA7AR148W mutation promotes lipid accumulation and NAFLD progression via increased localization on the hepatocyte surface.
  6. Semaphorin 7A Accelerates the Inflammatory Osteolysis of Periapical Lesions.
    Title: Semaphorin 7A Accelerates the Inflammatory Osteolysis of Periapical Lesions.
  7. Anoikis resistance in mammary epithelial cells is mediated by semaphorin 7a.
    Title: Anoikis resistance in mammary epithelial cells is mediated by semaphorin 7a.
  8. A homozygous R148W mutation in Semaphorin 7A causes progressive familial intrahepatic cholestasis.
    Title: A homozygous R148W mutation in Semaphorin 7A causes progressive familial intrahepatic cholestasis.
  9. The olfactory critical period is determined by activity-dependent Sema7A/PlxnC1 signaling within glomeruli.
    Title: The olfactory critical period is determined by activity-dependent Sema7A/PlxnC1 signaling within glomeruli.
  10. Sema7A is crucial for resolution of severe inflammation.
    Title: Sema7A is crucial for resolution of severe inflammation.
Submit: New GeneRIF Correction See all GeneRIFs (41)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chemorepellent activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables integrin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
NOT enables neuropilin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables semaphorin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables semaphorin receptor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within axon extension IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within axon extension IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within axon extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in integrin-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neural crest cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within olfactory lobe development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within olfactory lobe development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of axon extension IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of axon extension ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of axon extension ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of macrophage cytokine production IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synapse maturation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synapse maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in semaphorin-plexin signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
semaphorin-7A
Names
semaphorin-K1
semaphorin-L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011352.3 → NP_035482.1  semaphorin-7A precursor

    See identical proteins and their annotated locations for NP_035482.1

    Status: VALIDATED

    Source sequence(s)
    AC165246
    Consensus CDS
    CCDS23235.1
    UniProtKB/Swiss-Prot
    O88371, Q9QUR8
    Related
    ENSMUSP00000042211.8, ENSMUST00000043059.9
    Conserved Domains (3) summary
    cd11243
    Location:70 → 489
    Sema_7A; The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108)
    pfam01437
    Location:491 → 518
    PSI; Plexin repeat
    cl11960
    Location:547 → 617
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    57846879..57870148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244149.1 → XP_030100009.1  semaphorin-7A isoform X2

    Conserved Domains (4) summary
    pfam01437
    Location:275 → 324
    PSI; Plexin repeat
    cd00096
    Location:331 → 337
    Ig; Ig strand A [structural motif]
    cl11960
    Location:331 → 401
    Ig; Immunoglobulin domain
    cl15693
    Location:1 → 273
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  2. XM_006510889.4 → XP_006510952.1  semaphorin-7A isoform X1

    See identical proteins and their annotated locations for XP_006510952.1

    Conserved Domains (3) summary
    smart00423
    Location:333 → 360
    PSI; domain found in Plexins, Semaphorins and Integrins
    cl11960
    Location:389 → 459
    Ig; Immunoglobulin domain
    cl15693
    Location:2 → 331
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  3. XM_036154744.1 → XP_036010637.1  semaphorin-7A isoform X2

    Conserved Domains (4) summary
    pfam01437
    Location:275 → 324
    PSI; Plexin repeat
    cd00096
    Location:331 → 337
    Ig; Ig strand A [structural motif]
    cl11960
    Location:331 → 401
    Ig; Immunoglobulin domain
    cl15693
    Location:1 → 273
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  4. XM_006510888.4 → XP_006510951.1  semaphorin-7A isoform X1

    See identical proteins and their annotated locations for XP_006510951.1

    Conserved Domains (3) summary
    smart00423
    Location:333 → 360
    PSI; domain found in Plexins, Semaphorins and Integrins
    cl11960
    Location:389 → 459
    Ig; Immunoglobulin domain
    cl15693
    Location:2 → 331
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QUR8.1 GenPept UniProtKB/Swiss-Prot:Q9QUR8

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