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St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 [ Mus musculus (house mouse) ]

Gene ID: 20452, updated on 27-Nov-2024

Summary

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Official Symbol
St8sia4provided by MGI
Official Full Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4provided by MGI
Primary source
MGI:MGI:106018
See related
Ensembl:ENSMUSG00000040710 AllianceGenome:MGI:106018
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PST; PST-1; Siat8d; SIAT8-D; ST8SiaIV
Summary
Enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. Involved in sialylation. Predicted to be located in Golgi apparatus. Is expressed in several structures, including central nervous system; gut; hemolymphoid system gland; lung; and sensory organ. Orthologous to human ST8SIA4 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 5.6), whole brain E14.5 (RPKM 4.9) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See St8sia4 in Genome Data Viewer
Location:
1 D; 1 47.76 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (95515407..95595473, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (95587682..95667717, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01757 Neighboring gene predicted pseudogene 15427 Neighboring gene U7 small nuclear RNA, pseudogene 2 Neighboring gene STARR-positive B cell enhancer ABC_E987 Neighboring gene STARR-positive B cell enhancer ABC_E11079 Neighboring gene STARR-positive B cell enhancer ABC_E10023 Neighboring gene STARR-positive B cell enhancer mm9_chr1:97507476-97507777 Neighboring gene STARR-positive B cell enhancer mm9_chr1:97515913-97516213 Neighboring gene STARR-positive B cell enhancer ABC_E11080 Neighboring gene STARR-positive B cell enhancer ABC_E1225 Neighboring gene STARR-positive B cell enhancer ABC_E10024 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:97562784-97562967 Neighboring gene STARR-positive B cell enhancer ABC_E7736 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:97564187-97564374 Neighboring gene predicted gene, 30431 Neighboring gene STARR-positive B cell enhancer mm9_chr1:97589059-97589359 Neighboring gene RIKEN cDNA 4930598F16 gene Neighboring gene STARR-seq mESC enhancer starr_01758 Neighboring gene STARR-seq mESC enhancer starr_01759 Neighboring gene STARR-seq mESC enhancer starr_01760 Neighboring gene STARR-positive B cell enhancer ABC_E5786 Neighboring gene predicted gene, 22360

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Selective learning and memory impairments in mice deficient for polysialylated NCAM in adulthood. Markram K, et al. Neuroscience, 2007 Feb 9. PMID 17140740
  2. Remyelination after cuprizone induced demyelination is accelerated in mice deficient in the polysialic acid synthesizing enzyme St8siaIV. Koutsoudaki PN, et al. Neuroscience, 2010 Nov 24. PMID 20833231
  3. Polysialyltransferase overexpression in Schwann cells mediates different effects during peripheral nerve regeneration. Jungnickel J, et al. Glycobiology, 2012 Jan. PMID 21840969
  4. Polysialic acid affects pathophysiological consequences of status epilepticus. Pekcec A, et al. Neuroreport, 2010 Jun 2. PMID 20351597
  5. Mice deficient in the polysialyltransferase ST8SiaIV/PST-1 allow discrimination of the roles of neural cell adhesion molecule protein and polysialic acid in neural development and synaptic plasticity. Eckhardt M, et al. J Neurosci, 2000 Jul 15. PMID 10884307, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mice deficient for ST8SiaIV have impaired long-term spatial memory in two tasks that critically rely on the hippocampus.
    Title: Environmental enrichment rescues memory in mice deficient for the polysialytransferase ST8SiaIV.
  2. Results demonstrate that the early development of calbindin-positive periglomerular interneurons depends on the presentation of polysialic acid on NCAM and requires the activity of both St8sia2 and St8sia4
    Title: Deficits of olfactory interneurons in polysialyltransferase- and NCAM-deficient mice.
  3. NCAM-140 significantly promoted cell proliferation, motility and migration, while polysialylation of NCAM-140 catalyzed by STX, but not by PST, enhanced NCAM-mediated cell migration, but not cell proliferation or motility.
    Title: Promotion of cell migration by neural cell adhesion molecule (NCAM) is enhanced by PSA in a polysialyltransferase-specific manner.
  4. ST8SiaIV synthesized polySia selectively on a NRP2 glycoform that was characterized by the presence of sialylated core 1 and core 2 O-glycans.
    Title: Polysialic acid on neuropilin-2 is exclusively synthesized by the polysialyltransferase ST8SiaIV and attached to mucin-type o-glycans located between the b2 and c domain.
  5. Results indicate that the polySTs ST8SiaII and ST8SiaIV not only recognize an acidic patch in the FN1 domain of NCAM but also must contact sequences in the Ig5 domain for polysialylation of Ig5 N-glycans to occur.
    Title: The polysialyltransferases interact with sequences in two domains of the neural cell adhesion molecule to allow its polysialylation.
  6. the negative and positive effects of ST8SiaIV overexpression observed during peripheral nerve regeneration suggest that an optimized time- and differentiation-dependent control of expression in Schwann cells may further improve nerve regeneration
    Title: Polysialyltransferase overexpression in Schwann cells mediates different effects during peripheral nerve regeneration.
  7. While both ST8SiaII and ST8SiaIV mRNA levels decrease around the time of eye opening in mouse visual cortex, only ST8SiaII mRNA level reduction is regulated by sensory experience
    Title: Sensory experience differentially modulates the mRNA expression of the polysialyltransferases ST8SiaII and ST8SiaIV in postnatal mouse visual cortex.
  8. ST8Sia4 knockout mice display a decreased motivation in social interaction. This deficit can be partly explained by olfactory deficits and was associated with a clear decrease in PSA-NCAM expression in all brain regions analyzed.
    Title: Differential impact of polysialyltransferase ST8SiaII and ST8SiaIV knockout on social interaction and aggression.
  9. This study demonistrated that mice lacking St8siaIV polysialyltransferase have an accelerated onset of remyelination after cuprizone-induced demyelination.
    Title: Remyelination after cuprizone induced demyelination is accelerated in mice deficient in the polysialic acid synthesizing enzyme St8siaIV.
  10. In summary, the data suggest that the polysialic acid-neural cell adhesion molecule system is a putative target for the modulation of
    Title: Polysialic acid affects pathophysiological consequences of status epilepticus.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-glycan processing IEA
Inferred from Electronic Annotation
more info
  
involved_in N-glycan processing ISO
Inferred from Sequence Orthology
more info
  
involved_in ganglioside biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ganglioside biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oligosaccharide metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in oligosaccharide metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in sialylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sialylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase
Names
alpha-2,8-sialyltransferase 8D
polysialyltransferase-1
sialyltransferase 8 (alpha-2, 8-sialyltransferase) D
sialyltransferase 8D
sialyltransferase St8Sia IV
sialytransferase St8Sia IV
NP_001153217.1
NP_001407932.1
NP_001407933.1
NP_001407934.1
NP_033209.1
XP_036018814.1
XP_036018816.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159745.2 → NP_001153217.1  CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102483, AC104893
    Consensus CDS
    CCDS78661.1
    UniProtKB/TrEMBL
    A0A087WRA0
    Related
    ENSMUSP00000140534.2, ENSMUST00000189556.2
    Conserved Domains (1) summary
    pfam00777
    Location:94 → 262
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. NM_001421003.1 → NP_001407932.1  CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102483, AC104893

  3. NM_001421004.1 → NP_001407933.1  CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102483, AC104893

  4. NM_001421005.1 → NP_001407934.1  CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC102483, AC104893

  5. NM_009183.3 → NP_033209.1  CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform 1 precursor

    See identical proteins and their annotated locations for NP_033209.1

    Status: VALIDATED

    Source sequence(s)
    AC102483, AC104893
    Consensus CDS
    CCDS15201.1
    UniProtKB/Swiss-Prot
    Q64692
    UniProtKB/TrEMBL
    Q53WR7, Q6PAS1, Q8BY70
    Related
    ENSMUSP00000043477.5, ENSMUST00000043336.11
    Conserved Domains (1) summary
    pfam00777
    Location:94 → 353
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. NR_185227.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC102483, AC104893

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    95515407..95595473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162921.1 → XP_036018814.1  CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform X1

    Conserved Domains (1) summary
    pfam00777
    Location:189 → 357
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. XM_036162923.1 → XP_036018816.1  CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform X2

    Conserved Domains (1) summary
    pfam00777
    Location:189 → 357
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64692.1 GenPept UniProtKB/Swiss-Prot:Q64692

Gene LinkOut

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