Slc22a1 solute carrier family 22 (organic cation transporter), member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc22a1provided by MGI
Official Full Name: solute carrier family 22 (organic cation transporter), member 1provided by MGI
Primary source: MGI:MGI:108111
See related: Ensembl:ENSMUSG00000023829 AllianceGenome:MGI:108111
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lx1; Oct1; Orct; Orct1
Summary: Enables several functions, including organic cation transmembrane transporter activity; pyrimidine nucleoside transmembrane transporter activity; and toxin transmembrane transporter activity. Involved in several processes, including monoamine transport; quaternary ammonium group transport; and spermidine transport. Acts upstream of or within monoatomic cation transport. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including adrenal gland; liver; mammary gland; metanephros; and nasal cavity mucosa. Orthologous to human SLC22A1 (solute carrier family 22 member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver adult (RPKM 210.5), kidney adult (RPKM 182.5) and 4 other tissues See more
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Genomic context

Location:: 17 A1; 17 8.63 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (12867761..12894725, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (12648874..12675838, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of Mouse Organic Cation Transporter 2 for Nephro- and Peripheral Neurotoxicity Induced by Chemotherapeutic Treatment with Cisplatin.
Title: Role of Mouse Organic Cation Transporter 2 for Nephro- and Peripheral Neurotoxicity Induced by Chemotherapeutic Treatment with Cisplatin.
Amino acids in transmembrane helix 1 confer major functional differences between human and mouse orthologs of the polyspecific membrane transporter OCT1.
Title: Amino acids in transmembrane helix 1 confer major functional differences between human and mouse orthologs of the polyspecific membrane transporter OCT1.
Trospium Chloride Transport by Mouse Drug Carriers of the Slc22 and Slc47 Families.
Title: Trospium Chloride Transport by Mouse Drug Carriers of the Slc22 and Slc47 Families.
Functional and Pharmacological Comparison of Human, Mouse, and Rat Organic Cation Transporter 1 toward Drug and Pesticide Interaction.
Title: Functional and Pharmacological Comparison of Human, Mouse, and Rat Organic Cation Transporter 1 toward Drug and Pesticide Interaction.
OCT1 modulates multiple cardiometabolic traits through effects on hepatic thiamine content.
Title: Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content.
we unraveled substrate affinities and modulation of transport activity by acute regulation by protein kinases on mOCT1 and mOCT2
Title: Mouse organic cation transporter 1 determines properties and regulation of basolateral organic cation transport in renal proximal tubules.
Data indicate that the expression of the organic cation transporters Slc22a1, Slc22a2 and Slc22a3 essential for the cellular uptake of metformin was highly suppressed in Tsc1+/-renal tumours.
Title: Renal tumours in a Tsc1+/- mouse model show epigenetic suppression of organic cation transporters Slc22a1, Slc22a2 and Slc22a3, and do not respond to metformin.
Transcripts encoding OCT1-3 and ChAT (choline acetyltransferase) have been detected in tracheal epithelial cells; these data suggest that cells lining the airway are able to synthesize/secrete acetylcholine into the lumen.
Title: Luminal cholinergic signalling in airway lining fluid: a novel mechanism for activating chloride secretion via Ca²⁺-dependent Cl⁻ and K⁺ channels.
The influence of organic cation transporters 1, 2, and 3 (OCT1, OCT2, and OCT3) and their genetic variants on cellular uptake of picoplatin and on the individual components of the ensuing cytotoxicity such as DNA adduct formation, was determined.
Title: Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue.
the interaction of glucocorticoid receptor with Oct-1 on the beta-casein gene promoter
Title: Oct-1 functions as a transactivator in the hormonal induction of beta-casein gene expression.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc22a1 (e-PCR), detects polymorphism
- UniSTS:463367

Slc22a1 (e-PCR), detects polymorphism
- UniSTS:144418

U38652 (e-PCR)
- UniSTS:160618

Slc22a1 (e-PCR), detects polymorphism
- UniSTS:545989

D17Jcs63 (e-PCR), detects polymorphism
- UniSTS:259298

Slc22a1 (e-PCR), detects polymorphism
- UniSTS:233958

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables (R)-carnitine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables acetylcholine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables acetylcholine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables dopamine:sodium symporter activity	IEA Inferred from Electronic Annotation more info
enables dopamine:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables monoamine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables monoamine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables monoamine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables neurotransmitter transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables neurotransmitter transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables norepinephrine:sodium symporter activity	IEA Inferred from Electronic Annotation more info
enables norepinephrine:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables organic anion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables organic anion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables organic cation transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables organic cation transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic cation transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables putrescine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables putrescine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables pyrimidine nucleoside transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables pyrimidine nucleoside transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables quaternary ammonium group transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables quaternary ammonium group transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables secondary active organic cation transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables spermidine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables thiamine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables toxin transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables toxin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables xenobiotic transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables xenobiotic transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in (R)-carnitine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in acetylcholine transport	ISO Inferred from Sequence Orthology more info
involved_in acetylcholine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in acyl carnitine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular detoxification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular detoxification	ISO Inferred from Sequence Orthology more info
involved_in dopamine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in dopamine transport	ISO Inferred from Sequence Orthology more info
involved_in dopamine uptake	IEA Inferred from Electronic Annotation more info
involved_in dopamine uptake	ISO Inferred from Sequence Orthology more info
involved_in epinephrine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in epinephrine transport	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of transmembrane electrochemical gradient	IEA Inferred from Electronic Annotation more info
involved_in establishment or maintenance of transmembrane electrochemical gradient	ISO Inferred from Sequence Orthology more info
involved_in metanephric proximal tubule development	IEA Inferred from Electronic Annotation more info
involved_in monoamine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoamine transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic cation transport	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter transport	ISO Inferred from Sequence Orthology more info
involved_in norepinephrine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in norepinephrine transport	ISO Inferred from Sequence Orthology more info
involved_in norepinephrine uptake	IEA Inferred from Electronic Annotation more info
involved_in organic cation transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in organic cation transport	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin transport	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in putrescine transport	ISO Inferred from Sequence Orthology more info
involved_in putrescine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in quaternary ammonium group transport	ISO Inferred from Sequence Orthology more info
involved_in serotonin transport	IDA Inferred from Direct Assay more info	PubMed
involved_in serotonin transport	ISO Inferred from Sequence Orthology more info
involved_in serotonin uptake	IEA Inferred from Electronic Annotation more info
involved_in serotonin uptake	ISO Inferred from Sequence Orthology more info
involved_in spermidine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in spermidine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in thiamine transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in thiamine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in thiamine transport	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transport	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic transport	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transport across blood-brain barrier	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: solute carrier family 22 member 1

Names: mOCT1; organic cation transporter 1; solute carrier family 22, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009202.5 → NP_033228.2 solute carrier family 22 member 1

See identical proteins and their annotated locations for NP_033228.2

Status: PROVISIONAL

Source sequence(s)

AC167817

Consensus CDS

CCDS28393.1

UniProtKB/Swiss-Prot

O08966, Q9R1Q4

Related

ENSMUSP00000024596.9, ENSMUST00000024596.10

Conserved Domains (2) summary

cd06174
Location:125 → 515

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00898
Location:12 → 525

2A0119; cation transport protein