Slfn3 schlafen 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slfn3provided by MGI
Official Full Name: schlafen 3provided by MGI
Primary source: MGI:MGI:1329005
See related: Ensembl:ENSMUSG00000018986 AllianceGenome:MGI:1329005
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable RNA nuclease activity and ribosome binding activity. Acts upstream of or within negative regulation of cell population proliferation. Predicted to be located in cytosol and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; liver; sensory organ; and skeleton. Orthologous to several human genes including SLFN12L (schlafen family member 12 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver E14 (RPKM 2.2), liver E14.5 (RPKM 1.6) and 19 other tissues See more
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Genomic context

Location:: 11 C; 11 50.3 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (83082156..83105980)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (83191330..83215154)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vil-Cre specific Schlafen 3 knockout mice exhibit sex-specific differences in intestinal differentiation markers and Schlafen family members expression levels.
Title: Vil-Cre specific Schlafen 3 knockout mice exhibit sex-specific differences in intestinal differentiation markers and Schlafen family members expression levels.
Study characterized the role of Slfn3 in the intestinal homeostasis. Slfn3KO mice have a phenotype of decreased weight gain that is unlikely caused by a single gene but instead multiple genes/pathways. This includes the metabolic pathways of glycerolipid, linoleic and arachidonic acid metabolism, sex-dependent disregulation of glucose transporters, Glut2 and SGLT1, and intestinal differentiation genes, Notch2 and Cdx2.
Title: Schlafen 3 knockout mice display gender-specific differences in weight gain, food efficiency, and expression of markers of intestinal epithelial differentiation, metabolism, and immune cell function.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

General gene information

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Markers

Slfn3 (e-PCR), detects polymorphism
- UniSTS:507232

D13Die33 (e-PCR), detects polymorphism
- UniSTS:186738

AI450778 (e-PCR)
- UniSTS:165781

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA nuclease activity	ISO Inferred from Sequence Orthology more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: schlafen 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.