U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N [ Mus musculus (house mouse) ]

Gene ID: 20716, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Serpina3nprovided by MGI
Official Full Name
serine (or cysteine) peptidase inhibitor, clade A, member 3Nprovided by MGI
Primary source
MGI:MGI:105045
See related
Ensembl:ENSMUSG00000021091 AllianceGenome:MGI:105045
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Spi2-2; Spi2.2; Spi2/eb.4
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within response to bacterium; response to cytokine; and response to peptide hormone. Located in extracellular region. Is expressed in nervous system; sensory organ; skeleton; thymus primordium; and urinary system. Human ortholog(s) of this gene implicated in adult respiratory distress syndrome; chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 296.6), liver adult (RPKM 171.8) and 7 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Serpina3n in Genome Data Viewer
Location:
12 E; 12 54.17 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (104372967..104380588)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (104406646..104414334)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3M Neighboring gene STARR-seq mESC enhancer starr_33137 Neighboring gene predicted gene, 40561 Neighboring gene STARR-seq mESC enhancer starr_33138 Neighboring gene predicted gene, 24334 Neighboring gene STARR-seq mESC enhancer starr_33139 Neighboring gene predicted gene, 40562

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. SerpinA3N attenuates ischemic stroke injury by reducing apoptosis and neuroinflammation. Zhang Y, et al. CNS Neurosci Ther, 2022 Apr. PMID 34897996, Free PMC Article
  2. Serpina3n, Dominantly Expressed in Female Osteoblasts, Suppresses the Phenotypes of Differentiated Osteoblasts in Mice. Ishida M, et al. Endocrinology, 2018 Nov 1. PMID 30304388
  3. Muscle NAD(+) depletion and Serpina3n as molecular determinants of murine cancer cachexia-the effects of blocking myostatin and activins. Hulmi JJ, et al. Mol Metab, 2020 Nov. PMID 32599075, Free PMC Article
  4. Serpina3n is closely associated with fibrotic procession and knockdown ameliorates bleomycin-induced pulmonary fibrosis. Gong GC, et al. Biochem Biophys Res Commun, 2020 Nov 19. PMID 32900484
  5. A Potential Role for SerpinA3N in Acetaminophen-Induced Hepatotoxicity. Tran M, et al. Mol Pharmacol, 2021 Apr. PMID 33436521, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Serine protease inhibitor, SerpinA3n, regulates cardiac remodelling after myocardial infarction.
    Title: Serine protease inhibitor, SerpinA3n, regulates cardiac remodelling after myocardial infarction.
  2. SerpinA3N Regulates the Secretory Phenotype of Mouse Senescent Astrocytes Contributing to Neurodegeneration.
    Title: SerpinA3N Regulates the Secretory Phenotype of Mouse Senescent Astrocytes Contributing to Neurodegeneration.
  3. Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-kappaB signaling pathway in mice with temporal lobe epilepsy.
    Title: Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-κB signaling pathway in mice with temporal lobe epilepsy.
  4. SerpinA3N deficiency attenuates steatosis and enhances insulin signaling in male mice.
    Title: SerpinA3N deficiency attenuates steatosis and enhances insulin signaling in male mice.
  5. Neuronal Serpina3n is an endogenous protector against blood brain barrier damage following cerebral ischemic stroke.
    Title: Neuronal Serpina3n is an endogenous protector against blood brain barrier damage following cerebral ischemic stroke.
  6. Downregulation of Sepina3n Aggravated Blood-Brain Barrier Disruption after Traumatic Brain Injury by Activating Neutrophil Elastase in Mice.
    Title: Downregulation of Sepina3n Aggravated Blood-Brain Barrier Disruption after Traumatic Brain Injury by Activating Neutrophil Elastase in Mice.
  7. Serpin Signatures in Prion and Alzheimer's Diseases.
    Title: Serpin Signatures in Prion and Alzheimer's Diseases.
  8. SerpinA3N attenuates ischemic stroke injury by reducing apoptosis and neuroinflammation.
    Title: SerpinA3N attenuates ischemic stroke injury by reducing apoptosis and neuroinflammation.
  9. Longitudinal Single-Cell Transcriptomics Reveals a Role for Serpina3n-Mediated Resolution of Inflammation in a Mouse Colitis Model.
    Title: Longitudinal Single-Cell Transcriptomics Reveals a Role for Serpina3n-Mediated Resolution of Inflammation in a Mouse Colitis Model.
  10. SerpinA3n affects ovalbumin (OVA)-induced asthma in neonatal mice via the regulation of collagen deposition and inflammatory response.
    Title: SerpinA3n affects ovalbumin (OVA)-induced asthma in neonatal mice via the regulation of collagen deposition and inflammatory response.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acute-phase response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to cytokine IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to peptide hormone IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
serine protease inhibitor A3N
Names
alpha-1 antiproteinase
antitrypsin
serine (or cysteine) proteinase inhibitor, clade A, member 3N
serine protease inhibitor 2-2
serpin A3N

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009252.2 → NP_033278.2  serine protease inhibitor A3N precursor

    See identical proteins and their annotated locations for NP_033278.2

    Status: VALIDATED

    Source sequence(s)
    AC117194
    Consensus CDS
    CCDS26152.1
    UniProtKB/Swiss-Prot
    Q62258, Q91WP6
    UniProtKB/TrEMBL
    G3X8T9
    Related
    ENSMUSP00000021506.6, ENSMUST00000021506.6
    Conserved Domains (1) summary
    cd19551
    Location:37 → 418
    serpinA3_A1AC; serpin family A member 3, alpha 1-antichymotrypsin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    104372967..104380588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91WP6.1 GenPept UniProtKB/Swiss-Prot:Q91WP6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools